Drug Eruptions/Mechanisms Flashcards
Non-allergic skin conditions?
Psoriasis,
Eczema,
Phototoxicity,
Skin erosion from steroids, Pigmentation
Common presentation of a reaction to something non-allergic?
maculopapular, exanthematous rash
Most likely group of the population to experience a drug eruption?
young women
Most common type of drug eruption?
exanthematous
What does an exanthematous drug eruption look like on the skin?
widespread, symmetrical rash with itch usually sparing the the mucous membranes
What kind of hypersensitivity reaction is an exanthematous drug eruption
T cell mediated type 4
Common drugs associated with exanthematous drug eruptions?
penicillins, NSAIDs, anti-epileptics
Common drugs associated with urticarial drug reactions?
B lactam antibiotics, aspirin, opiates, NSAIDs, muscle relaxants
Drugs known to cause acne?
glucocorticoids, androgens, lithium
What kind of drug eruption does acne come under?
pustular/bullous
Drugs known to cause bullous pemphygoid?
ACEi, penicillin, furosemide
Describe the appearance of a fixed drug eruption on the skin
Well demarcated round plaques usually on the hands, genitals, lips. Look red and painful
Drugs associated with fixed drug eruptions
tetracyclines, paracetamol, NSAIDs
Name an acute phototoxic drug reaction
skin toxicity
photodegradation
Name a chronic phototoxic reaction
pigmentation
photoageing
photocarcinogenesis
