Pathology of Non-Pigmented Lesions

Question 1

what kind of precancerous dysplasias can occur on the skin?

Answer 1

actinic keratoses, viral lesions, bowen’s disease

Question 2

name a benign epidermal tumour

Answer 2

seborrhoeic keratosis

Question 3

what is the cause of horn cysts?

Answer 3

thickened keratin in the epidermis

Question 4

why do seborrhoeic keratoses appear?

Answer 4

acanthosis and hyperkeratosis in the epidermis

Question 5

3 types of BCC?

Answer 5

nodular
superficial
infiltrative

Question 6

best technique to remove a BCC

Answer 6

moh’s surgery

Question 7

what does an infiltrative BCC look like on a microscope?

Answer 7

desmoplasia causing a very fibrous stroma

Question 8

name a dysplastic viral precursor

Answer 8

HPV (type 16)

Question 9

which skin cancer is associated with appearing on burns and ulcers?

Answer 9

SCC

Question 10

is there a risk of metastasis in SCC and if so is it high/low?

Answer 10

yes, low

Question 11

appearance of SCC on histology

Answer 11

prickly desmosomes (like fingers) and keratin (look for cells with a pink halo)

Question 12

histological appearance of bowen’s disease

Answer 12

FULL thickness dysplasia of keratinocytes in epidermis

Question 13

histological appearance of actinic keratoses

Answer 13

PARTIAL thickness dysplasia of epidermal keratinocytes

Question 14

does bowen’s disease progress rapidly or slowly?

Answer 14

slowly