Path 8 Myometrium Flashcards
1
Q
Endometrial carcinoma (hyperplastic)
A
Via endometrial hyperplasia (estrogen)
- 75%
- Endometroid histology
- PTEN, p53 mutation
2
Q
Endometrial carcinoma (sporadic)
A
Via atrophic endometrium, no precursor lesion
- 25%
- Serous papillary histology
- p53 overexpression
3
Q
Cowden syndrome
A
PTEN mutation
- multiple hemartomas
- increased Breast, Thyroid, Endometrial carcinoma
4
Q
MMMT
A
Malignant Mixed Mullerian Tumor
- Endometrial carcinoma/sarcoma
- Muscle, cartilage, glands
- Postmenopausal
5
Q
Leiomyoma
A
Fibroid
- Benign smooth muscle neoplasm
- Related to estrogen (fertile periods)
6
Q
Leiomyosarcoma
A
Cellular atypia and mitotic activity
- 40-60 y/o
- Tendency to recur and metastasize
