Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Test 10 > Path 11 Bone Pathology > Flashcards

Path 11 Bone Pathology Flashcards

1
Q

Osteoid main component

A

Type 1 collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Osteocalcin

A

Vit K dependent

-Binds to hydroxyapatite -> mineralization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Osteonectin

A

Calcium binding protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hydroxyapatite crystals

A

CaPO4 packed around collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Achondroplasia

A

FGF-R3 gene mutation (chondrocyte proliferation)

-Sporadic or autosomal dominant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Osteogenesis Imperfecta

A

Improper Type 1 collage synthesis

  • Autosomal dominant
  • Recurrent fractures
  • Blue sclera
  • Hearing/Dental abnormalities
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Osteopetrosis

A

Carbonic anhydrase II mutation (Howship lacunae)

  • No remodelling, bones fill up
  • Recessive/Malignant, Dominant/Benign
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Osteopetrosis clinical

A

Extramedullary hematopoiesis (Hepatosplenomegaly)

  • Erlenmeyer flask deformities
  • Neural foramina compression
  • Renal tubular acidosis (CA II mutation -> decreased HCO3 resorption)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Rickets

A

Childhood Vit D deficiency

-Pigeon chest, bowing long bones, frontal bossing, rachitic rosary (rib cartilage)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Osteomalacia

A

Adult vit D deficiency

  • Weak bones
  • Increased osteoid on histo
  • Down Ca, PO4
  • Up Alk Phosph, PTH
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Osteoporosis

A

Reduced bone mass, degenerating matrix

  • Vertebral and Hip fractures
  • Avoid glucocorticoids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Osteoporosis Dx

A

DEXA scan

-labs are normal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Paget disease

A

Osteoclast dysfunction in elderly

  • Osteoclasts hyperresponsive to RANK
  • Paramyxovirus etiology
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Paget disease phases

A

1- Osteolytic phase (osteoclasts)
2- Mixed phase (osteoblast overdrive)
3- Osteosclerotic phase (both stop)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Paget disease histo

A

Mosaic pattern of lamellar and woven bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Paget disease clinical

A

Hat gets tighter
Lion facies
Hearing loss
Bone deformity/fracture

17
Q

Avascular osteonecrosis

A

Children and adolescents

  • Carpal bones and head of femur
  • Osteoarthritis if subchondral bone involved
18
Q

Osteomyelitis causes (1)

  • Most common
  • Sexually active
  • Diabetics
A
  • Staph Aureus
  • Gonorrhea
  • Pseudomonas
19
Q

Osteomyelitis causes (2)

  • Children
  • Sickle cell
  • Dog bites
  • Direct spread
A
  • H. influenzae
  • Salmonella
  • Pasteurella
  • Mixed bacterial
20
Q

Sequestrum

A
  • Acute

- Bone necrosis due to suppurative/ischemic injury

21
Q

Involucrum

A
  • Chronic

- Reactive bone deposition around infected bone

Test 10 (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions