Path 13 Joint

Question 1

Heberden nodes

Answer 1

Osteophytes in fingers due to osteoporosis

Question 2

Eburnation

Answer 2

Polishing of exposed bone

Question 3

Pannus

Answer 3

Proliferative synovitis with inflammatory cell infiltrate

-Rheumatoid Arthritis

Question 4

RA joint fusion

Answer 4

Ankylosis

Question 5

Rheumatoid factor

Answer 5

IgM against Fc of self-IgG

Question 6

Rheumatoid Dx severity marker

Answer 6

ACPA - Anti Citrullinated Peptide Ab

Question 7

RA acute phase reactants (elevated inflammatory markers)

Answer 7

CRP (c-reactive protein)

ESR

Question 8

RA progression

Answer 8

Antigen -> Helper T (CD4) -> cytokines -> T & B proliferation -> neutrophil accumulation -> synovial proliferation

Question 9

Felty syndrome

Answer 9

RA + splenomegaly + neutropenia

Question 10

Caplan syndrome

Answer 10

RA + pneumoconiosis

Question 11

Spondyloarthropathies

Answer 11

HLA-B27

-Seronegative (no Ab) arthritis of peripheral joints and spine

Question 12

Ankylosing spondylitis

Answer 12

Young men with HLA-B27

-may develop amyloidosis or cardiac involvement

Question 13

Reiter syndrome

Answer 13

Conjuctivitis, uveitis, urethritis

-HLA-B27

Question 14

Enteropathic arthritis

Answer 14

UC, Chron’s disease

Question 15

Gout

Answer 15

Monosodium urate crystals

-Tophi are large chalky aggregates

Question 16

Podagra

Answer 16

Big toe acute arthritis

Question 17

Chronic tophaceous gout

Answer 17

Joint deformity/destruction

Question 18

Secondary gout causees

Answer 18

• Leukemia
• Lesch-Nyhan syndrome (X-linked)
• Chronic renal disease

Question 19

Lesch-Nyhan syndrome

Answer 19

HGPRT deficiency

-decreased purine recycling -> xanthine -> uric acid

Question 20

Pseudo-gout

Answer 20

Calcium pyrophosphate crystals

Question 21

Tenosynovial Giant Cell Tumor

Answer 21

Giant cells

-Hemosiderin-laden histiocytes