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Test 10 > Path 4 Vagina/Cervix > Flashcards

Path 4 Vagina/Cervix Flashcards

1
Q

Herpes location

A

Cervix, usually

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2
Q

MCV identify

A

Intracytoplasmic viral inclusions

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3
Q

Trichomonas identify

A

Strawberry cervix

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4
Q

Puerperal

A

Post-partum

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5
Q

PID identify

A

Elevated ESR

Elevated C-reactive protein

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6
Q

Bartholin’s cyst

A

Unilateral, painful cystic lesion

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7
Q

Condyloma acuminatum cause

A

HPV 6, 11

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8
Q

HPV histo

A

Koilocytosis (large nuclei in squamous cells)

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9
Q

2 types lof vulva leukoplakia

A
  • Lichen Sclerosus

- Lichen simplex chronicus

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10
Q

Lichen sclerosus

A

Atrophic, thinned epidermis (elderly)

-Risk of sq carcinoma

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11
Q

Lichen simplex chronicus

A

Epidermal hyperplasia

  • Chronic irritation and itching
  • No cancer risk
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12
Q

VIN

A

Vulvar Intraepithelial Neoplasia

  • HPV 16 (young women)
  • Multicentric sq carcinoma in situ
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13
Q

Non HPV vulva carcinoma

A

Keratinizing squamous cell

  • Keratin pearls
  • Sometimes from lichen sclerosus (elderly women)
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14
Q

Glandular Neoplastic Lesions

A

Extramammary Paget Disease

  • Map-like erythematous lesion
  • High recurrence rate following excision
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15
Q

Extramammary Paget Disease histo

A

Confined to epidermis

-PAS and Keratin positive

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16
Q

VAIN

A

Vaginal Intraepithelial Neoplasia

  • Precursor lesion to sq carcinoma
  • HPV related
17
Q

Sarcoma Botryoides

A

Embryonal rhabdomyosarcoma

-Young child with grape like masses protruding from vagina

18
Q

DES (diethylstilbesterol) causes

A

Adenosis and Clear Cell Adenocarcinoma

19
Q

Adenosis

A

Persistance of columnar epithelium in upper 1/3 vagina

20
Q

Clear Cell Adenocarcinoma

A

Malignant glands with clear cytoplasm

-From adenosis

21
Q

Endocervical Polyps

A

Benign exophytic growths

-Irregular vaginal bleeding

22
Q

Cervical cancer

A

HPV 16, 18, 31, 33

  • Oral contraceptives
  • Lots of sex
23
Q

HPV cancer mechanism

A

Produce E6 and E7 proteins

-Destroy p53 and Rb

24
Q

Cervical cancer location

A

Squamo-columnar junction (os)

25
Q

CIN

A

Cervical Intraepithelial Neoplasia

-Graded as LSIL or HSIL (high grade squamous intraepithelial lesion)

26
Q

CIN grading

A

CIN 1 (LSIL) can regress

27
Q

HSIL/HPV staining

A

Ki-67

p16

28
Q

Early microinvasive cervical cancer Tx

A

Cone biopsy

29
Q

Invasive cervical cancer Tx

A

Hysterectomy w/lymph node dissection, irradiation

30
Q

Cervical cancer mortality

A

Due to local extension rather than metastasis

Test 10 (24 decks)

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