Micro 3 Chlamydia

Question 1

Chlamydia micro

Answer 1

G- rods

Question 2

Chlamydia cell wall

Answer 2

LPS (G-)
No peptidoglycan (penicillin ineffective)

Question 3

Chlamydia stages

Answer 3

Elementary bodies infect (small, extracellular)

Reticulate bodies replicate (larger, intracellular)

Question 4

Chlamydia internalization

Answer 4

Inhibit phagosome-lysosome fusion

• Reorganize into RB, replicate
• Extrusion (reverse endocytosis)

Question 5

Chlamydia extrusion v lysis

Answer 5

Extrusion - C. trachoma, C. pneumoniae

Lysis - C. psittaci

Question 6

Chlamydia systemic infection

Answer 6

Reactive arthritis (Reiter's syndrome)
-Inflammatory (sterile) arthritis, Conjunctivitis, Urethritis

Question 7

Reiter’s syndrome

Answer 7

Can’t pee, can’t see, can’t climb a tree

Question 8

Chlamydia painful manifestation

Answer 8

Lymphogranuloma venereum

• Inguinal lymph node buboes, ulceration
• Elephantiasis
• Fever, headache, myalgia

Question 9

Reactive Arthritis HLA

Answer 9

HLA-B27

Question 10

Chlamydia Tx

Answer 10

Azithromycin (1 dose)

-Tetracycline (more doses)

Question 11

Tetracycline MOA

Answer 11

Ribosome 30s subunit

Question 12

Tetracycline resistance

Answer 12

Kept out of cells

-plasmid mediated

Question 13

Azithromycin MOA

Answer 13

Ribosome 50s subunit

Question 14

Neonatal C. trachomatis conjunctivitis Tx

Answer 14

Erythromycin and/or tetracycline eye ointment

Question 15

Haemophilus ducreyi disease

Answer 15

Chancroid: painful genital ulcers (ragged edges) with inguinal adenopathy

Question 16

Haemophilus ducreyi micro

Answer 16

G- coccobacilli

Question 17

H. ducreyi identify

Answer 17

Culture

-Long strand parallel rows (schools of red fish)

Question 18

H. ducreyi geography

Answer 18

SE asia, sub-saharan africa

Question 19

H. ducreyi Tx

Answer 19

Ceftriaxone, Azithromycin

Question 20

Klebsiella granulomatis disease

Answer 20

Donovanosis (Granuloma inguinale)

• Beefy red painless granulomatous ulcer with rolled edges
• Subcutaneous granulomas

Question 21

Klebsiella granulomatis identify

Answer 21

Biopsy

-Intracellular Donovan bodies

Question 22

K. granulomatis Tx

Answer 22

Doxycycline

Question 23

Genital mycoplasma/ureaplasma

Answer 23

Probably normal flora

-Lack of animal models = lack of Koch’s postulates

Question 24

Urethritis myco cause

Answer 24

Mycoplasma genitalium