Path 7 Breast Cancer Flashcards
1
Q
Genetic breast cancer disease
A
Li-Fraumeni syndrome
-p53 allele mutation
2
Q
Intraductal carcinoma
A
Cribriform pattern in ducts
- Hyperplasia is more disorganized
- Papillae have no fibrovascular core
- Comedonecrosis
3
Q
Lobular carcinoma in situ
A
Well defined cytoplasmic borders
-Monotonous sheets v cribriform
4
Q
Paget’s disease
A
From intraductal carcinoma
-CEA stain
5
Q
Invasive ductal carcinoma (70%) Tx
A
E-R (nuclear) - Tamoxifen
HER2/NEU (membrane) - Herceptin
6
Q
Medullary carcinoma
A
Subtype of infiltrating ductal carcinoma
- Marked lymphocytic infiltrate
- Better prognosis
7
Q
Colloid (Mucinous) Carcinoma
A
Tumor cells in lake of basophilic mucin
-Better prognosis
8
Q
Tubular carcinoma
A
Looks sort of normal
-No myoepithelial layers (must stain)
9
Q
Infiltrating lobular carcinoma (5%)
A
Non palpable
- Indian file cells
- Bull’s eye pattern
10
Q
Poor prognostic indicator
A
c-erbB2 protooncogene amplification
11
Q
Gynecomastia histo
A
Randomly dispersed acini
