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IHN: Biochemistry 2 > Pantothenic acid (B5) > Flashcards

Pantothenic acid (B5) Flashcards

1
Q

pantothenic acid foods

A

ALL foods
high in liver, egg yolks, milk

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2
Q

pantothenic acid bioavailability

A

40-60%

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3
Q

pantothenic acid is easily destroyed by __ and __ so it is lost in __ foods

A

pantothenic acid is easily destroyed by heating and freezing so it is lost in processed foods

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4
Q

is pantothenic acid safe at high doses?

A

yes, but very high may cause diarrhea

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5
Q

food form of pantothenic acid

A

coenzyme A

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6
Q

pantothenic acid excretion

A

urine

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7
Q

pantothenic acid transporter

A

SMVT, Na-dependent symporter

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8
Q

__% of ingested pantothenic acid is absorbed

A

50% of ingested pantothenic acid is absorbed

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9
Q

absorbable form of PA

A

pantothenic acid

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10
Q

pantothenic acid is not __ prior to excretion

A

pantothenic acid is not metabolized prior to excretion
excreted intact

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11
Q

what is unique about pantothenic acid excretion?

A

it is excreted intact

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12
Q

absorption of pantothenic acid

A
  1. CoA –> PA
  2. PA enters enterocyte via SMVT
  3. PA sent into portal circulation OR stays in cell and becomes CoA
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13
Q

supplement form of PA

A

pentothenol

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14
Q

__ % of ingested PA is absorbed

A

50 % of ingested PA is absorbed

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15
Q

2 biological functions of PA

A

cofactor in
1. coenzyme A
2. acyl carrier protein (ACP)

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16
Q

PA is synthesized in

A

microbes

17
Q

PA can make

A

CoA

18
Q

what inhibits PA –> CoA

A

CoA

19
Q

__ inhibits PA –> CoA, but __ reverses this inhibition

A

CoA inhibits PA –> CoA, but carnitine reverses this inhibition

20
Q

main function of Coenzyme A

A

acyl group transfer via ACP

21
Q

ACP function

A

fatty acid synthesis

22
Q

coenzyme A causes

A

acyl group transfer

23
Q

assessment of PA status

A

urinary excretion of PA

24
Q

is PA deficiency common?

A

it is the rarest

25
Q

people at risk

A

conditions that increase vitamin need
diabetes, alcoholism, bowel disease

26
Q

symptoms of PA deficiency

A

burning feet syndrome
vomiting, fatigue weakness, irritability

27
Q

PA deficiency treatment

A

calcium-panthothenate

28
Q

what cofactor is needed with PA treatment?

A

calcium

29
Q

what vitamin deficiency is the rarest?

A

pantothenic acid
it really only occurs as a part of multiple deficiencies

IHN: Biochemistry 2 (38 decks)

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