CoQ10 Flashcards

1
Q

CoQ10 is found in

A

plant and animal foods

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2
Q

CoQ10 aka

A

ubiquinon

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3
Q

CoQ10 is __ and __ soluble

A

CoQ10 is hydrophobic and lipid soluble

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4
Q

CoQ10 is like

A

a vitamin

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5
Q

CoQ10 is present in __ cells, mainly in __ and __

A

CoQ10 is present in all cells, mainly in mitochondria and cytosol

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6
Q

CoQ10 main function

A

transfer of electrons in ETC
cellular respiration

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7
Q

high energy demand = __ conc of CoQ10

A

high energy demand = high conc of CoQ10

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8
Q

__ is involved in production of CoQ10

A

HMG-CoA reductase

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9
Q

___ lowers cholesterol by blocking __ which also lowers production of __

A

statins lowers cholesterol by blocking HMG-CoA reductase which also lowers production of CoQ10

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10
Q

CoQ10 is invorporated into

A

chylomicrons
VLDL (post-prandial)
LDL

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11
Q

__ enhance absorption of CoQ10 into enterocyte

A

dietary lipids enhance absorption of CoQ10 into enterocyte

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12
Q

CoQ10 is synthesized endogenously from __

A

acetyl-CoA

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13
Q

does dietary CoQ10 require a transporter?

A

NO

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14
Q

dietary CoQ10 is absorbed __ and __ carry it away to cells

A

dietary CoQ10 is absorbed passively and chylomicrons carry it away to cells

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15
Q

the GI tract __ absorbs CoQ10 bc:

A

the GI tract poorly absorbs CoQ10 bc:
CoQ10 is large
no enzymes can degrade it

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16
Q

most CoQ10 comes from

A

endogenous synthesis

17
Q

95% of CoQ10 in circulation is __ (fully __ form)

A

95% of CoQ10 in circulation is ubiquinol (fully reduced form)

18
Q

main function of CoQ10

A

electron transport

19
Q

CoQ10 is highly concentrated in tissues that require a lot of

A

energy
like the heart

20
Q

ubiquinone and lipoproxidation

A

ubiquinone (reduced CoQ10) donates its electron to qunch an oxygen

21
Q

CoQ10 excretion

A

urine and feces