(P7) Bones and joints pathology/Soft tissue tumors (Lab 28)

Question 1

Identify

Answer 1

Fibrous dysplasia

Question 2

Identify

Answer 2

Osteitis deformans (Paget disease)

Question 3

identify and label

Answer 3

Fibrous dysplasia

Question 4

Q. indicated structures ?

Answer 4

• Osteitis deformans (Paget disease)*
• Osteoblasts/Osteoclasts/Osteocytes

Question 5

Q. this lesion could be associated with infection of the following microorganism?

Answer 5

Osteitis deformans (Paget disease)

-Paramyxoviruses (measles/RSV)

Question 6

Q. What type of disease does this lesion cause?

Q. What type of mutation can occur and resulting in an increase in what activity?

Q. Anatomical localization?

Answer 6

Osteitis deformans (Paget disease)

• -Paget disease (chronic disease with disordered Remodeling of the bone)*
• -Mutation in SQSTMI gene* which leads to inc. activity of NF-kB —>osteoclasts inc.
• -Axial skeletal, proximal femur*

Question 7

Identify

Answer 7

Osteosarcoma

Question 8

Q. The most typical anatomical location?

Q. Reactive, metaplastic lesion that should be considered in the differential diagnosis of the lesion?

Answer 8

Osteosarcoma

• Knee (dystal femur, proximal tibia)
• Myositis ossificans-

Question 9

Identify

Answer 9

Giant cell tumor (osteoclastoma)

Question 10

Label

Answer 10

Question 11

Indentify

Answer 11

Metastatic gastric signet ring cell carcinoma in the bone

Question 12

Label

Answer 12

Question 13

Q. Special staining helpful in detection of this lesion?

Q. This type of lesion has only one type of activity?

Q. It most commonly involves what type of bone and is considered to be

Q. In children?

Answer 13

• Metastatic gastric signet ring cell carcinoma*
• in the bone*
• -Mucicarmine-*
• Osteoclastic activity-
• Most commont malignant bone tumor (vertebral column), brest, prostate, lung, thyroid, kidney
• Children: from Neuroblastoma, Wilms tumor, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma

Question 14

Identify

Answer 14

Gouty tophi of the skin

Question 15

Q. Homogenous substance present on the slide ?

Answer 15

• Gouty tophi of the skin*
• Urate crystal (uric acid)

Question 16

Label

Answer 16

Question 17

Q. This lesion is pathognomonic hallmark of what?

Q. Aggregation of this substace ___ __ is surrounded by what 3 infiltrates

Answer 17

Gouty tophi of the skin

• -Gout-*
• -Uric Acid-*
• -Macorphages/Lymphocytes, foreign body giant cells-*

Question 18

Identify

Answer 18

Rheumatoid arthritis

Question 19

Q. Give definition of rheumatoid factor?

Answer 19

Rheumatoid arthritis

-multiple antibodies; IgM, sometimes IgG or IgA directed against the Fe frament of IgG

Question 20

Q. indicate structures

Answer 20

Question 21

Identify

Answer 21

Synovial sarcoma

Question 22

Q. does the name of this lesion indicate its orgin?

Q. Most common anatomical location fo this lesion?

Answer 22

Synovial sarcoma

• -no, it is unclear-*
• Deep soft tissue-circumscribed, round or multilobulated mass attached to teh tendon, tendon sheets, or exterior wall of the joint capsule

Question 23

Label

Answer 23