(P7) Bones and joints pathology/Soft tissue tumors (Lab 28) Flashcards
Identify
Fibrous dysplasia
Identify
Osteitis deformans (Paget disease)
identify and label
Fibrous dysplasia
Q. indicated structures ?
- Osteitis deformans (Paget disease)*
- Osteoblasts/Osteoclasts/Osteocytes
Q. this lesion could be associated with infection of the following microorganism?
Osteitis deformans (Paget disease)
-Paramyxoviruses (measles/RSV)
Q. What type of disease does this lesion cause?
Q. What type of mutation can occur and resulting in an increase in what activity?
Q. Anatomical localization?
Osteitis deformans (Paget disease)
- -Paget disease (chronic disease with disordered Remodeling of the bone)*
- -Mutation in SQSTMI gene* which leads to inc. activity of NF-kB —>osteoclasts inc.
- -Axial skeletal, proximal femur*
Identify
Osteosarcoma
Q. The most typical anatomical location?
Q. Reactive, metaplastic lesion that should be considered in the differential diagnosis of the lesion?
Osteosarcoma
- Knee (dystal femur, proximal tibia)
- Myositis ossificans-
Identify
Giant cell tumor (osteoclastoma)
Label
Indentify
Metastatic gastric signet ring cell carcinoma in the bone
Label
Q. Special staining helpful in detection of this lesion?
Q. This type of lesion has only one type of activity?
Q. It most commonly involves what type of bone and is considered to be
Q. In children?
- Metastatic gastric signet ring cell carcinoma*
- in the bone*
- -Mucicarmine-*
- Osteoclastic activity-
- Most commont malignant bone tumor (vertebral column), brest, prostate, lung, thyroid, kidney
- Children: from Neuroblastoma, Wilms tumor, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma
Identify
Gouty tophi of the skin
Q. Homogenous substance present on the slide ?
- Gouty tophi of the skin*
- Urate crystal (uric acid)
Label
Q. This lesion is pathognomonic hallmark of what?
Q. Aggregation of this substace ___ __ is surrounded by what 3 infiltrates
Gouty tophi of the skin
- -Gout-*
- -Uric Acid-*
- -Macorphages/Lymphocytes, foreign body giant cells-*
Identify
Rheumatoid arthritis
Q. Give definition of rheumatoid factor?
Rheumatoid arthritis
-multiple antibodies; IgM, sometimes IgG or IgA directed against the Fe frament of IgG
Q. indicate structures
Identify
Synovial sarcoma
Q. does the name of this lesion indicate its orgin?
Q. Most common anatomical location fo this lesion?
Synovial sarcoma
- -no, it is unclear-*
- Deep soft tissue-circumscribed, round or multilobulated mass attached to teh tendon, tendon sheets, or exterior wall of the joint capsule
Label
