(P2) Dis. of Imm: Polyarteritis nodosa (the heart) (268)

Question 1

Name this slide :)

1. Above the central strucure to the UR- group of darker cells clummped together
2. Name the central structure

and what surrounds it

3. LR of slide ____ surrounded by adipose tissue

Answer 1

Polyarteritis nodosa (the heart)

• 1. Fibrinoid necrosis*
• 2. obliterated lumen-surrounding the Lumen is the wall of the artery*
• 3. vessel surrounded by adipose tissue*

4. Thickening of intima and media with occlusion of blood vessel lumen

5. Infiltrates consists in early disease of neutrophils, followed by plasma cells, lymphocytes and macrophages.

Question 2

• name this slide :)*
  1. Most commonly affected organ
  2. Without treatment this leads to…
  3. Stains that can be used:

Answer 2

Polyarteritis nodosa (the heart)

1. kidney, heart, skin, skeletal muscle

2. death

3. H&E and Azan staining

Question 3

Polyarteritis nodosa (the heart)

Q 1. The typical organs involved in the course of this disease are:

NAME 4:

Q2. symptoms depend on what ?

Answer 3

1. kidney

heart

skin

skeletal

muscle

mesentery

2. the affected Organ

Question 4

name this slide :)

• Name all characteristics of the slide*
• that apply*

Answer 4

Polyarteritis nodosa (the heart)(H&E)

• 1. Obliterated narrow vessel lumen*
• 2. Fibrinoid necrosis*
• 3. Hyperplasia of Collagen fibers (lighter color purple)*
• 4. line of inflammatory infiltrates extending from vessel lumen*

Question 5

Polyarteritis nodosa (the heart)(H&E)

Name the Stages:

Answer 5

1. Deposit of immune complexes (in small and medium arteries)
2. Inflammation (transmural inflammation of the arterial wall)
3. Fibrinoid necrosis in vessel wall
4. Fibrosis

Note: all stages may coexist in the same vessel

Question 6

Polyarteritis nodosa (the heart)(H&E)

Causes what:

Define:

Answer 6

1. Acute necrotizing vasculitis of small or medium-sized muscular arteries

a. typically renal* and *visceral

2. Ischemia and i_nfarction_ of affected tissue

3. Lesions may involve entire cicurmference of the vessel wall or part of it

4. Central fibrinoid necrosis

5.Thrombosis in affected arteries, infarcts (narrowing of capillary lumen), aneurysms

Question 7

Fibrinoid necrosis

Define:

Answer 7

Fibrinoid necrosis

is a specific pattern of irreversible, uncontrolled cell death that occurs when antigen-antibodycomplexes are deposited in the walls of blood vessels along with fibrin.

It is common in the immune-mediated vasculitides which are a result of type III hypersensitivity.

When stained with hematoxylin and eosin, they appear brightly eosinophilic and smudged

Question 8

name this slide :)

Name the staining

Answer 8

Polyarteritis nodosa (the heart)

(azan)

Question 9

name the slide

name the stain

and

color of the stain

what can be visualized as a result of this stain

Answer 9

Polyarteritis nodosa (the heart) (azan)

Azan staining –

FIBRINOID NECROSIS is RED

Question 10

DESCRIBE THE

Acute and Chronic phase

of Polyarteritis nodosa

Answer 10

Acute phase – infiltration of i_nflammatory cells_

Chronic phase – less inflammatory cells, more fibrosis

Question 11

name this slide

• Give 4 organs in which this lesion*
• is obseved most frequently*

Answer 11

1. Heart
2. Kidney
3. GI tract
4. Skin