(P4) Cardiac: Polyarteritis nodosa (the kidney)

Question 1

identify:

Answer 1

Polyarteritis nodosa (the kidney)

1. infarcts leading to renal failure
2. fibrinoid necrosis

Question 2

Identify slide:

describe this lesion:

Answer 2

Polyarteritis nodosa (the kidney)

Small and medium-sized muscular arteries – children and young adults

Kidney, mesenteric artery, heart, skeletal muscle

Question 3

Identify slide:

Clinical manifestations are?

Answer 3

Polyarteritis nodosa (the kidney)

Clinical manifestations

malaise, fever, weight loss, hypertension, abdominal pain, melena (blood in the stool), infarction

Question 4

Polyarteritis nodosa (the kidney)

Gross appearance:

Answer 4

Thick wall of artery (rosary), narrow lumen

Question 5

Identify:

Microscopically:

Answer 5

Polyarteritis nodosa (the kidney)

Microscopically

• Fibrinoid necrosis:

A. Eosinophilic mass that stains for fibrin

-Inflammation:

B. Neutrophils, lymphocytes, plasma cells and macrophages are present in the arterial wall and often is associated with disruption of the vessel wall aneurysm formation

Question 6

Polyarteritis nodosa (the kidney)

What happens to the immune complexes during this condition, kidneys and the lumen?

Answer 6

Immune complex deposition in the wall of blood vessels, type 3 hypersensitivity reaction

Kidneys (renal failure), skeletal muscle, heart (MI), CNS (stroke), skin and mesentery (intestinal infarct)

Narrowing of the lumen → thrombosis, infarcts in affected organs

Question 7

identify:

Answer 7

Question 8

Identify:

Answer 8

Polyarteritis nodosa (the kidney)

Question 9

identify:

Answer 9

Polyarteritis nodosa (the kidney)

Question 10

Name the serious consequence of this disease in the presented organ

Answer 10

Infarcts: renal failure

Question 11

Type of necrosis typical of this lesion is called:

Answer 11

Fibrinoid necrosis

Question 12

identify:

Q: Infarct in this lesion leads to what?

Answer 12

Polyarteritis nodosa (the kidney)

Q: Renal Failure