(P2) Dis. of Imm: Hashimoto thyroiditis (459)

Question 1

Name this slide

1. Define this disease:
2. It is also known as what?

Answer 1

Hashimoto thyroiditis

1. it is inflammation of Thyroid Gland with a presence of aTPO i aTPG antiboidis

2. known as chronic lymphocytic thyroiditis and Hashimoto’s disease, is an autoimmune disease in which the thyroid gland is gradually destroyed

Question 2

• name this slide :*
• What 2 clinical presentations*
• are*
• distinguishable:*

Answer 2

Hashimoto thyroiditis

• 1. With goiter (more common)*
• 2. Atrophic*

Definition: abnormal enlargement of your thyroid gland

Question 3

Hashimoto thyroiditis

Most commonly causes what Condition in developed countries?

Answer 3

Hypothyroidism

• Definition:*
• Hypothyroidism, or underactive thyroid, develops when the thyroid gland fails to produce or secrete as muchthyroxine (T4) as the body needs.*
• Because T4 regulates such essential functions as heart rate, digestion, physicalgrowth, and mental development, an insufficient supply of this hormone can slow life-sustaining processes,damage organs and tissues in every part of the body, and lead to life-threatening complications.*

Question 4

• Hashimoto thyroiditis*
• Microscopic findings:*

Answer 4

1. Infiltrates of lymphocytes and plasma cells within thyroid parenchyma

2. Lymphoid follicles with germinal centers are formed

3. Destruction and atrophy of thyroid follicles

4. Adicophillic (axyphilic) metaplasia of follicular epithelial cess rich in mitochondria (Hurthle or Askanazy cells)

Question 5

Name the slide:

• 1. Name the largest and darkest tructure*
• 2. Clear looking -different size and shape cells are called*
• 3. What else can be observed in this slide*

Answer 5

Hashimoto thyroiditis

1. Lymphoid follicel w/germinal center

2. Colloid in follicle

3. Infiltrates of lymphocytes and plasma cells within thyroid parenchyma

Question 6

name this slide

Microscopically:

What can you find withing the GERMINAL CENTERS?

Answer 6

Hashimoto thyroiditis

Presence of lymphoid follicles

(the dark ring around the germinal center)

• -Atrophy of thyroid follicles*
• -Interstitial fibrosis*

Question 7

• What orther condition can be caused*
• as a result of*
• Hashimoto thyroiditis*

Name and Define:

Answer 7

Oxyphilic metaplasia – Hurthle cells (cells with eosinophilic cytoplasm)

▪ Hurthle cells – is a cell in the thyroid that is often associated with Hashimoto as well as follicular thyroid cancers

▪ Characterized as enlarged epithelial cells* with *abundant eosinophilic granular cytoplasm* as a result of *altered mitochondria

Question 8

name this slide

• 1. This disease most commonly leads to?*
• 2.* Does this cause an increase of hormone secretion in the late stages of the disease?

Answer 8

Hashimoto thyroiditis

• 1. Hypothyroidism*
• 2. NO (hypothyroidism)*