(P4) Cardiac: Hyaline arteriolosclerosis of the kidney Flashcards
Identify Slide :
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/542/077/q_image_thumb.png?1613492187)
Hyaline arteriolosclerosis of the kidney
Hypertension** and **diabetes mellitus
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/542/077/a_image_thumb.png?1613492281)
Identify:
What causes this leasion?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/542/188/q_image_thumb.png?1613497465)
Hyaline arteriolosclerosis of the kidney
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/542/188/a_image_thumb.png?1613497518)
-Chronic hypertension leads to reactive changes in the smaller arteries and arterioles throughout the body.
These changes are collectively referred to as arteriosclerosis.
-In the arterioles, the alterations are also known as arteriolosclerosis
Hyaline arteriolosclerosis of the kidney
What happens to the wall of the arterioles ?
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/552/943/q_image_thumb.png?1613497832)
- The wall of the arterioles is thickened by the deposition of basement membrane material and by the accumulation of plasma proteins
- The arterioles exhibit smooth muscle cell proliferation and increased amounts of intercellular* *collagen* and *glycosaminoglycans*, resulting in an *onion-skin appearance
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/552/943/a_image_thumb.png?1613497858)
Identify:
Glomeruli afferent arteriole:
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/553/369/q_image_thumb.png?1613497931)
Hyaline arteriolosclerosis of the kidney
_Glomeruli afferent arteriol_e:
- Hyaline arteriosclerosis in benign nephrosclerosis (benign hypertension)
- -Hyperplastic arteriosclerosis* in malignant hypertension:
a. Fibrinoid necrosis
b. Proliferation of intima with myxoid change
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/553/369/a_image_thumb.png?1613498293)
Hyaline arteriolosclerosis of the kidney
Microscopically;
The small muscular arteries display new layers of elastin.
Presenting as a reduplication of the internal elastic lamina* and *increased connective tissue
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/554/631/a_image_thumb.png?1613498510)
Hyaline arteriolosclerosis of the kidney
Macroscopically:
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/258/q_image_thumb.png?1613498547)
Macroscopically
- Thickening and hyalinization of the wall
- Smooth muscle cell proliferation – onion skin
- Narrowing of the lumen, regional scars in kidney parenchyma
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/258/a_image_thumb.png?1613498627)
Hyaline arteriolosclerosis of the kidney
-This lesion is most requently seen in what type of patients?
Most frequent: Heart patients, common in DM
Identify:
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/522/q_image_thumb.png?1613498741)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/522/a_image_thumb.png?1613498768)
Identify:
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/601/q_image_thumb.png?1613498792)
Hyaline arteriolosclerosis of the kidney
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/601/a_image_thumb.png?1613498819)
Identify:
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/737/q_image_thumb.png?1613498867)
Hyaline arteriolosclerosis of the kidney
![](https://s3.amazonaws.com/brainscape-prod/system/cm/336/555/737/a_image_thumb.png?1613498884)