(P4) Cardiac: Malignant nephrosclerosis (H&E) & (Azan)

Question 1

Identify:

Answer 1

Malignant nephrosclerosis (H&E)

1. azan
2. fibrinoid necrosis

Question 2

Identify the slide:

Answer 2

Malignant nephrosclerosis (H&E)

Question 3

Identify slide:

Answer 3

Malignant nephrosclerosis (azan)

1. Blue: Connective tissue
2. Dark pink: tufts of corpuscles with fibrin 3. H &E
3. Periarteritis nodosa
4. fibrinoid necrosis
5. Azan stain is used to stain the fibrin. Fibrin is characteristic for this lesion because it deposits into the vessel wall after injury to the endothelium

Question 4

identify:

Answer 4

Malignant nephrosclerosis (azan)

Question 5

Lable and Identify:

Answer 5

Question 6

Identify and Lable

Answer 6

Malignant nephrosclerosis (H&E)

Question 7

Identify and Define:

Answer 7

• Malignant nephrosclerosis (H&E)*
• -Form of renal disease associated with malignant phase of hypertension*
• -S_mall muscular arteries_ – segmental dilation as a result of necrosis of smooth muscle cells*

Question 8

Malignant nephrosclerosis is descirbed by what occurances dealing with fibrin and proteins?

Answer 8

Fibrin and the entry of plasma proteins into the vessel wall.

-The combination of cell necrosis and deposition of plasma proteins is termed – fibrinoid necrosis.

T-he period of acute injury is rapidly followed:

A. Smooth muscle proliferation

B. Striking concentric increase in the number of layers of smooth muscle cells

Result – onion-skin appearance

Question 9

what are the complications of Malignant nephrosclerosis ?

Answer 9

Complications

Increased intracranial pressure, renal failure, 50% of mortality within 3 months of onset

Note: elevated BP (severe or malignant)

-Fibrinoid Necrosis of walls of small renal arteries, afferent arerioles, glomerular loops.

Question 10

Malignant nephrosclerosis

Answer 10

Micro:

1) Fibrinoid Necrosis of arterioles: wall of blood vessel is eosinophilic and granular (red in Azan staining)
2) Hyperplastic arteriolitis: onion -skinning

Question 11

This staining also is helpful in the diagnisis of the following lesion presented on the slide during this test?

Answer 11

Polyarteritis Nodosa

Question 12

This staining method seen on the slide is also helpful in the diagnisis of the following vascular disease?

Answer 12

Periarteritis nodosa

(inflammation of the outer coat and tissues surrounding an artery)