(P2) Dis. of Imm: Scleroderma (the skin)

Question 1

• Name this slide :)*
• 1. Name the pinkish/purple outline on the*
• surface of slide*
• 2. What strucute is missing at the Stratum Basale?*

Answer 1

Scleroderma (the skin)

• 1.* thin atrophic epidermis
• 2. Loss of rete pegs*

Question 2

name this slide :)

• Name all the that apply to the*
• observation of this slide*

Answer 2

Scleroderma (the skin)

• 1. Thin atropic epiderms*
• 2. Loss of Rete Pegs*
• 3. In the Dermis- no appandages (hair follicles)*
• 4. Wave like collagen deposits*

Question 3

Scleroderma (the skin)

What parts of the body does this affect?

Answer 3

skin

lungs

GI

heart

kidneys

Question 4

Name this slide :)

Define CREST Syndrome

Answer 4

C - Calcinosis (calcium deposits in skin)

R - Raynaud Phenomenon,

E- Esophageal dysmotility (acid reflex, increased motility of esophagous)

S- Sclerodactylyl (thickening and tightening of the sking on the fingers and hands)

T- Teleangiectasia (dilaton of capillaries causing red marks on surface of the skin)

Question 5

Define Rete Pegs in

Scleroderma (the skin)

Answer 5

Epithelial extentions that project into underlying connective tissue

Question 6

Scleroderma (the skin)

Q. Give staining method useful indetection fo late stage?

Answer 6

Van Gieson

Question 7

SS- Systemic Scleroderma

define:

Answer 7

Systemic scleroderma, or systemic sclerosis,

• 1. autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called fibrosis, in the skin and internal organs and by injuries to small arteries (vasculopathy=disease of blood vessels)*
• 2. There are 2 major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse.*