(P2) Dis. of Imm: Rheumatoid nodule (the skin) (215)

Question 1

Name this slide

What type of disease is this

What parts of body are involved

Sex group/age group affected

Answer 1

• Rheumatoid nodule (the skin)*
• 1. Systemic, chronic inflammatory disease*
• 2. Involves joints symmetrically and bilaterally*
• 3. Small joints – hands, wrist, elbows & ankles*
• 4. Women 30-50 yrs*

Question 2

Rheumatoid nodule (the skin)

Define the

Rheumatoid factor:

Answer 2

RF – 80% of cases, autoantibody; multiple antibodies, IgM, sometimes IgG or IgA direct against the Fc fragments of IgG

Question 3

Rheumatoid nodule (the skin)

Q. This disease is always preceded by the following disease

Answer 3

rheumatoid arthritis

Note:

These nodules occur almost exclusively in association with rheumatoid arthritis. Very rarely do rheumatoid nodules occur as rheumatoid nodulosis (multiple nodules on the hands or other areas) in the absence of rheumatoid arthritis.

Question 4

Name this slide

and

Describe the characteristics

Answer 4

• “Rheumatoid nodule”*
• Subcutaneous rheumatoid nodule with:*
• Large area of fibrinoid necrosis, surrounded by palisade of Macrophages and inflammaroty cells.*

Question 5

Name the inflammatory cells surrounging the

rheumatoid nodule

Answer 5

Rim of Histocytes (macrophage)

inflammatory infiltrate consisting of

lymphocytes and plasma cells

Question 6

• Rheumatoid nodule (the skin)*
  1. What type of disease is this (define)?
  2. What parts of the body does it affect?

Answer 6

1. systemic, chronic inflammatory disease

2. joints of the hand, wrist, elbows, and ankles

Question 7

name this slide

Most likely fate (outcome) of this lesion is…

Answer 7

Rheumatoid nodule (the skin)​

Fibrosis