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All the Small Things > p450 Facts > Flashcards

p450 Facts Flashcards

1
Q

What is the effect on p450 enzymes (inducer or inhibitor): ketoconazole

A

inhibitor

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2
Q

What is the effect on p450 enzymes (inducer or inhibitor): St. John’s Wort

A

Inducer

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3
Q

What is the effect on p450 enzymes (inducer or inhibitor): Macrolides

A

Inhibitor

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4
Q

What is the effect on p450 enzymes (inducer or inhibitor): Griseofulvin

A

Inducer

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5
Q

What are the drugs that inhibit p450 enzymes?

A
  • Acute EtOH abuse
  • Ritonavir
  • Amiodarone
  • Cimetidine/cipro
  • Ketoconazole
  • Sulfonamides
  • INH
  • Grapefruit
  • Quinidine
  • Macrolides

(“AAA RACKs IN GQ Magazine”)

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6
Q

What is the effect on p450 enzymes (inducer or inhibitor): Carbamazepine

A

Inducer

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7
Q

What is the effect on p450 enzymes (inducer or inhibitor): Grapefruit juice

A

Inhibitor

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8
Q

What is the effect on p450 enzymes (inducer or inhibitor): Phenobarbital

A

Inducer

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9
Q

What is the effect on p450 enzymes (inducer or inhibitor): cimetedine

A

inhibitor

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10
Q

What is the effect on p450 enzymes (inducer or inhibitor): Quinidine

A

Inhibitor

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11
Q

What is the effect on p450 enzymes (inducer or inhibitor): Nevirapine

A

Inducer

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12
Q

What is the effect on p450 enzymes (inducer or inhibitor): chronic EtOH abuse

A

Induces

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13
Q

What is the effect on p450 enzymes (inducer or inhibitor): Acute EtOH abuse

A

Inhibits

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14
Q

What is the effect on p450 enzymes (inducer or inhibitor): sulfonamide

A

Inhibitor

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15
Q

What is the effect on p450 enzymes (inducer or inhibitor): amiodarone

A

inhibitor

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16
Q

What is the effect on p450 enzymes (inducer or inhibitor): INH

A

Inhibitor

17
Q

What is the effect on p450 enzymes (inducer or inhibitor): Phenytoin

A

Inducer

18
Q

What are the drugs that induce p450 enzymes?

A 
EtOH
St. John's wort
-Phenytoin
-Phenobarbital
-Nevirapine 
-Rifampin
-Griseofulvin
-Carbamazepine

(“Chronic alcoholics Steal Phen Phen and Never Refuse Greasy Carbs”)

19
Q

What is the effect on p450 enzymes (inducer or inhibitor): ritonavir

A

Inhibitor

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