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All the Small Things > Drugs > Flashcards

Drugs Flashcards

1
Q

What is the coenzyme that is dysfunctional in malignant PKU?

A

THB

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2
Q

What is the rate determining step in the dopamine/epi/NE pathway?

A

Tyrosine Hydroxylase

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3
Q

What is the drug that inhibits tyrosine hydroxylase?

A

Metyrosine

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4
Q

What is the enzyme that takes L-DOPA to dopamine?

A

Dopa decarboxylase

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5
Q

What is the inhibitor of DOPA decarboxylase?

A

Carbidopa

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6
Q

What is the enzyme that takes NE to epinephrine?

A

N-methyl-transferase

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7
Q

Where does the DOPA pathway occur?

A

Adrenal glands

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8
Q

Where in the cell does N-methyltransferase rxn occur?

A

From the***

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9
Q

What is the enzyme that produces melanin?

A

Tyrosinase (take L-DOPA and turns it into melanin)

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10
Q

What are the enzymes that degrade NE?

A

COMT

MAO

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11
Q

What is the degradation product of NE?

A

Vanillylmandelic acid

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12
Q

What is the major neurotransmitter dysfunction with AD?

A

Low ACh

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13
Q

What is the MOA of scopolamine?

A

Anti ACh to treat nausea

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14
Q

What is the treatment for HCV? (3)

A

Simeprevir
Ribavirin
Sofosbuvir

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15
Q

What are the neurotransmitter defects in HD?

A

Low GABA

Low ACh

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16
Q

What are the neurotransmitters that are out of whack with schizophrenia?

A

High dopamine

High 5HT

17
Q

What is the MOA of amiloride?

A

Blocks ENaC

18
Q

What is the MOA of triamterene?

A

Blocks ENaC

All the Small Things (29 decks)

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