P (003) BLOOD GROUP SYSTEM

Question 1

the null phenotype of P

Answer 1

“p” = p null phenotype

Question 2

Sources of P1 Ag:

Answer 2

• Hydatid cyst fluid
• Pigeon eggs
• Common earth worm

note: can be used to neutralize Anti-P1 Abs in serum sample

Question 3

Most cold-reactive antibody of P blood group:

Answer 3

Anti-P1 (IgM)

Question 4

Antibodies produced by all p null individuals; components are separable; IgM/IgG (wide thermal range)

Answer 4

Anti-PP1P^k

Note:
- The anti-P, anti-P1, and anti-P^k components of anti-PP1P^k are separable through adsorption
- Components of anti-PP1P^k have shown to be IgM and IgG.
- They react over a wide thermal range and efficiently bind complement, which makes them potent hemolysins.
- Anti-PP1P^k has the potential to cause severe HTRs and HDFN

Question 5

Antibody found in all P^k individuals; has wide thermal range

Answer 5

AlloAnti-P

Question 6

Biphasic IgG (reacts at 30-37C); found in patients with PCH; also known as “Donath-Landsteiner Ab”

Answer 6

AutoAnti-P