BLOOD GROUP ANTIBODIES

Question 1

Antibody production occurs even without exposure to RBC antigen

Answer 1

Naturally occurring antibodies

Question 2

Antibody production occurs after exposure to RBC antigen

Answer 2

Immune antibodies

Question 3

Naturally occurring antibody type:

Answer 3

IgM

Question 4

Immune antibodies antibody type:

Answer 4

IgG

Question 5

Optimal temperature reactivity of IgM antibodies

Answer 5

<22C or 4-22C

Question 6

Optimal temperature reactivity of IgG antibodies:

Answer 6

37C (body temperature)

Question 7

Examples of Naturally occurring antibodies

Answer 7

• ABO
• Hh
• MN
• Ii
• Lewis
• P
  antibodies

Question 8

Examples of Immune antibodies:

Answer 8

• Rh
• Kell
• Kidd
• Duffy
• Ss
  antibodies

Question 9

Any antibody that reacts ar or near body temperature (30-37C) regardless of specificity, is intentionally clinically significant, which can cause HTR or HDN

Answer 9

Clinically Significant Antibodies

Question 10

Antibody type(s) that can cause Hemolytic Transfusion Reaction (HTR)

Answer 10

IgG or IgM

Question 11

Antibody type(s) that can cause Hemolytic Disease of the Newborn (HDN)

Answer 11

IgG only (because IgG is the only Ig type that can cross the placenta)