MNS BLOOD GROUP SYSTEM (002)

Question 1

MNS antigen that is found on GPA (glycophorin A)

Answer 1

MN antigen

note: MN antigen along with Ss, and U antigen are part of the integral proteins on the RBC membrane; they are destroyed by enzymes and exhibits dosage effect

Question 2

MNS antigen that is found on GPB (glycophorin B)

Answer 2

Ss antigen
U antigen

note: MN antigen along with Ss, and U antigen are part of the integral proteins on the RBC membrane; they are destroyed by enzymes and exhibits dosage effect

Question 3

MNS antibodies that are mostly cold-reactive:

Answer 3

Anti-N (IgM)

Question 4

MNS antibody that is pH dependent; strongly reacts at acidic pH (<6.5)

Answer 4

Anti-M (IgM)

Question 5

MNS antibodies: IgM, reacts at 37C/AHG reactive:

Answer 5

Anti-S
Anti-s
Anti-U (common in S-s-U individuals)

Question 6

MNS antibodies that causes HDN and HTR:

Answer 6

Anti-S, Anti-s, Anti-U

Question 7

MNS genes:

Answer 7

GYPA and GYPB
- encoded in chromosome 4
- code for GPA and GPB