MISCELLANEOUS BLOOD GROUPS

Question 1

The Di^a antigen is useful tool in anthropologic studies of ________________ ancestry

Answer 1

Mongolian, Asian, & South American Indians

Question 2

Antigens of Cartwright (011) (Yta & Ytb) are located on ______________ which is an enzyme involve in neurotransmission:

Answer 2

Acetylcholinesterase (AchE)

Question 3

Xg allele is located on the petite (short) arm of the __________ . Antigen is sensitive to most enzyme

Answer 3

X chromosome

note: The Xg antigen is common in females

Question 4

Scianna (013) antigens are located on RBC adhesion protein - ______________

Answer 4

Erythropcyte Membrane associated protein (ERMAP)

Question 5

Dombrock (014) Ags are located on _____________ that anchors them to the RBC membrane

Answer 5

GPI-linked glycoprotein (Glycosyl-Phosphatidyl-Inositol)

Question 6

Colton (015) Ags are located on integral transmembrane protein known as __________, involved in osmotic water transport

Answer 6

Aquaporin-1

Note: other name of Aquaporin-1 = Channel-Forming Integral Protein (CHIP)

Question 7

The Landsteiner-Wiener (LW 016) antigens has phenotypic similarities with:

Answer 7

Rh Antigens

Question 8

LW (016) antigens are located on a glycoprotein known as:

Answer 8

Intracellular adhesion molecule 4 (ICAM-4)

Question 9

Chido/Rodgers (017) antigens are located on _____ and adsorbed from plasma onto the RBC membrane

Answer 9

Complement C4

Note:
- Antigens are sensitive/destroyed to most enzymes
- C4-coated RBCs is routinely used in Ab screening to confirm presence of Anti-Ch/Rg

Question 10

Gerbich (020) antigens are located on ________________.

Answer 10

Glycophorin C or D

Question 11

Three Gerbich-negative phenotypes:

Answer 11

1. Yus type
2. Gerbich type
3. Leach type (null phenotype) associated with Elliptocytes

Question 12

Cromer (021) Ags are located on ____________

Answer 12

Decay Accelerating Factor (DAF/CD55)

Note: DAF is a regulatory protein for Complement

Question 13

Knops (022) Ags are located on ___________:

Answer 13

Complement receptor 1 (CR1/CD35)

Note: Found on RBCs

Question 14

Indian (023) antigens are located on the _____________ glycoprotein, which is present on most tissues

Answer 14

CD44 glycoprotein

Question 15

It’s presence in a complex with the Rh proteins is essential for Rh antigen expression (co-expressor of Rh antigens)

Answer 15

Rh-associated glycoprotein (030)

Question 16

HLA Class I Ags detectable on mature RBC:

Answer 16

Bga - HLA-B7
Bgb - HLA-B17
Bgc - HLA-A28