Kell (006) BLOOD GROUP SYSTEM

Question 1

Kell antigen that has an incidence rate of 9%

Answer 1

K (Kell) antigen

Question 2

Kell antigen that has an incidence rate of 99.8%

Answer 2

k (Cellano) antigen

Question 3

Kp and Js antigens:

Answer 3

1. Kpa - 2%
2. Kpb - 99.9%
3. Jsa - 0-20%
4. Jsb - 80-100%

Note: antigens can be destroyed by;
- DTT
- AET
- 2-ME
- ZZAP
- EDTA-glycine acid

Question 4

Most common after ABO/Rh antibodies; IgG, 37C/AHG reactive

Answer 4

Anti-K

Note: All Kell antibodies are IgG antibodies; they are all clinically significant

Question 5

Kell antibody that is rarely encountered

Answer 5

Anti-k

Note: All Kell antibodies are IgG antibodies; they are all clinically significant

Question 6

Kell antibody that is produced by Ko (null phenotype) individual.; recognizes all Kell antigen; can cause HTR, HDFN

Answer 6

Anti-Ku

Note: All Kell antibodies are IgG antibodies; they are all clinically significant

Question 7

Kell gene:

Answer 7

KEL - expressed in chromosome 7

NOTE:
Kell Ag is rated second to D in immunogenecity

Question 8

Arrangement of most immunogenic blood antigen:

Answer 8

1. A, B, A1, AB (ABO antigens)
2. Rh D
3. K (Kell)

Question 9

Weak espression of Kell Ags: k, Kpb, Jsb; X-linked inheritance; Associated conditions: muscular dystrophy, acanthocytosis, CGD

Answer 9

Mcleod phenotype