Ovarian Pathology and Ovarian Cancer Flashcards

1
Q

List some of the high risk families syndromes which increase risks of ovarian cancer.

A

HNPCC/Lynch syndrome
BRCA1
BRCA2

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2
Q

What is another RF of ovarian cancer?

A

Women who haven’t had children

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3
Q

Where can ovarian cancer originate from?

A

Fallopian tubes
Pre-existing benign ovarian cysts

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4
Q

RECAP- what is the role of the pathology team in ovarian cancer?

A

Determine the type of tumour, the tumour grade, tumour stage

This helps with diagnosis, treatment and prognosis for the patient

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5
Q

What are the symptoms of ovarian cancer?

A

Vague symptoms!!

Indigestion/early satiety/poor appetite
Altered bowel habit/pain
Bloating/discomfort/weight loss

Pelvic mass- asymptomatic or pressure symptoms e.g. bladder dysfunction, getting up to the toilet in the night

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6
Q

How is a diagnosis of ovarian cancer made?

A

Surgical/pathological based
US scan abdomen and pelvis
CT scan
CA 125

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7
Q

What is the ovarian related tumour marker?

A

CA 125

->important to note not only raised in ovarian cancer

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8
Q

When else may CA 125 be raised?

A

Malignancy- ovarian, colon, pancreas, breast

Menstruation
Endometriosis
Liver disease
Recent surgery

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9
Q

What does stage 1 of ovarian cancer mean?

A

Cancer limited to ovaries with capsule intact

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10
Q

What does stage 2 of ovarian cancer mean?

A

Cancer of one or both ovaries with pelvic extension

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11
Q

What does stage 3 of ovarian cancer mean?

A

Cancer of one or both ovaries with peritoneal implants outside pelvis

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12
Q

What does stage 4 of ovarian cancer mean?

A

Distant metastasis

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13
Q

Treatment of ovarian cancer?

A

Chemotherapy
Surgery

->chemo can be adjuvant or neo-adjuvant

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14
Q

In surgery for ovarian cancer, what is the point of the surgery?

A

To clear the disease
To obtain tissue diagnosis
To stage the disease

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15
Q

What is first line chemo for ovarian cancer?

A

Platinum and taxane, within 8wks of surgery

->cure unlikely by there can be complete or partial response. Average response is two years

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16
Q

Which targeted therapies can be used in treatment of ovarian cancer?

A

PARPi (Poly ADP Ribose Polymerase Inhibitors

17
Q

Name three PARPi which has been approved for use in Scotland.

A

Olaparib
Niraparib
Rucaparib

18
Q

What can be done in treatment/management of patients with a reoccurrence of ovarian cancer?

->reoccurrence is common

A

Chemo
Palliative care
Surgery in some
Tamoxifen

19
Q
A