Cervical Screening Flashcards

1
Q

Which type of cancer is most commonly linked to HPV?

A

Cervical cancer

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2
Q

Which other cancers are associated with HPV?

A

Penis
Vulva/vagina
Anus
Mouth
Oropharynx

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3
Q

How is HPV transmitted?

A

Close physical contact, often penetrative sex

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4
Q

What age group are more likely to get HPV?

A

Young people, approx. 15-20

->90% of people clear the HPV infection by their own immune system

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5
Q

Which two types of HPV are the oncogenic types?

A

HPV 16
HPV 18

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6
Q

What is done for the primary prevention of HPV?

A

HPV immunisations

->started in 2008, boys included in 2019

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7
Q

Who is offered HPV vaccine?

A

Secondary children aged 12-13

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8
Q

What is one risk factor for cervical cancer?

A

Smoking

->interestingly, while genetics can increase chances if it runs in the family, this isn’t as much as other cancers as it tends to be caused by HPV infection

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9
Q

What test is used for cervical screening?

A

SMEAR tests

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10
Q

Which part of the cervix needs to be tested for HPV in a SMEAR test?

A

Transformation zone

->this is the are that there are changes seen from HPV to precancer

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11
Q

If there are any minor changes in a SMEAR test, which further test may be carried out?

A

Colposcopy - test to take a closer look at the cervix

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12
Q

How often are SMEARS taken?

A

Every 5yrs from age of 25-64

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13
Q

What technique is used in smear tests>

A

Liquid based cytology

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14
Q

Dyskaryosis?

A

Abnormal cytology of the cervix

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15
Q

What are some of the nuclear features of dyskaryosis?

A

Increased size, increased nucelar:cytoplasmic ratio
Variation in size/shape
Coarse irregular chromatin

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16
Q

Which type of cell reflects HPV infection?

A

Koliocytes

17
Q

Like previously mentioned, normal smears are repeated every five years.

However, how often is a smear repeated if the patient is positive for HPV but the cytology is normal?

A

Repeat test in one year

18
Q

What should be done if there is dyskaryosis on a smear test sample?

A

Refer to colposcopy

19
Q

A women gets an invitation to book a colposcopy appointment, What would be the most likely reason for this:

A. Her HPV test is positive
B. She has high risk HPV and low grade dyskaryosis
C. She has low grade dyskaryosis or BNA on cytology
D. Her smear test was unsatisfactory or failed
E. Her smear taker thought her cervix looked abnormal

A

B.

20
Q

What happens in colposcopy?

A

Magnification and light to see the cervix

21
Q

What does a colposcopy allow for?

A

Exclusion of obvious malignancy
Use to acetic acid +/- lodene to identify limits of lesion, select biopsy site and define an area to treat

22
Q

What will be done if colposcopy is done and the cervix looks normal?

A

Discharged back to have smear repeated in community

23
Q

What will be done if colposcopy is done and there is low grade changes?

A

May also be discharged and get another smear in a year

But if unsure, small punch biopsy may be done

24
Q

What will be done if colposcopy is done and high grade changes were seen?

A

Punch biopsy to make diagnosis and then offer treatment

25
Q

List the low risk types of HPV

A

6, 11, 42, 44

26
Q

What may be seen in those with low risk HPV?

A

Genital warts
Low grade CIN

->often transient and resolve

27
Q

List the high risks types of HPV.

A

16, 18

-> 21 and 45 but less so

28
Q

What may be seen in those with high risk types of HPV?

A

Persistent infection
Increased risks of high grade CIN and cancer

29
Q

How does HPV cause high grade CIN?

A

Persistent infection

->viral DNA integrates into host cell genome. Over expression of viral E6 and E7 proteins leading to deregulation of host cell cycle

30
Q

CIN?

A

Cervical intraepithelial neoplasia

->disorganised proliferation of abnormal cells in squamous epithelium (dysplasia)

31
Q

CIN 1?

A

Low grade dysplasia- will regress

32
Q

CIN 2?

A

Moderate dysplasia- may regress

33
Q

CIN 3?

A

Severe dysplasia- unlikely to regress. Precursor of invasive cancer

34
Q

Treatment of CIN 2/3?

A

Excuse transformation zone of cervix
Ablate the transformation zone of cervix

35
Q

Why is important to follow up patients after treatment of CIN?

A

They are at a higher risk of cervical cancer

36
Q

What is the aim of cervical screening?

A. Detect cervical dyskaryosis
B. Reduce the risk of cervical cancer
C. Detect CIN
D. Prevent cervical cancer
E. Reduce high risk HPV infections

A

Reduce risks of cervical cancer

->by detecting high risk HPV and cervical dyskaryosis

37
Q
A