Osteoporosis Treatment

Question 1

bisphosphonates - examples

Answer 1

“-dronates”:
*alendronate
*risedronate
*zoledronate
*ibandronate

Question 2

bisphosphonates (“-dronates”) - MOA

Answer 2

*pyrophosphate analogs
*bind hydroxyapatite in bone → inhibit osteoclast activity & PROMOTE OSTEOCLAST APOPTOSIS → lower net bone resorption / inhibition of bone breakdown
*used as first-line therapy to treat osteoporosis and other bone conditions

examples: alendronate, risedronate, zoledronate, ibandronate

Question 3

bisphosphonates (“-dronates”) - ADEs

Answer 3

*ESOPHAGITIS and esophageal ulcers
*osteonecrosis of jaw
*atypical femoral stress fractures

Question 4

denosumab - MOA

Answer 4

*a monoclonal antibody against RANK-L (receptor activator of nuclear factor kappaB ligand)
*prevents RANKL from activating osteoclasts, therefore reducing bone resorption
*used to treat osteoporosis and other bone conditions

Question 5

PTH analogs - examples

Answer 5

*teriparatide
*abaloparatide

“para” in the name → PARAthyroid hormone analog

Question 6

teriparatide, abaloparatide - MOA

Answer 6

*PTH analogues used to treat osteoporosis and other bone conditions
*MOA: recombinant PTH analog; administered in a PULSATILE fashion to INCREASE OSTEOBLAST activity

Question 7

teriparatide, abaloparatide - ADEs

Answer 7

*dizziness
*tachycardia
*orthostatic hypotension
*transient hypercalcemia
*muscle spasms