Opioids

Question 1

Which are Class II?

Answer 1

morphine, fentanyl

Question 2

mu agonist

Answer 2

morphine, fentanyl

Question 3

morphine acts on which receptors?

Answer 3

mu, delta, and kappa but mu the best

Question 4

is a partial agonist at the mu receptor and greater affinity at kappa receptor

Answer 4

Butorphanol

Question 5

highest density of opioid receptors found in the

Answer 5

brain, spinal cord, GI tract

Question 6

analgesia receptors

Answer 6

mu, kappa or delta

Question 7

respiratory depression receptors

Answer 7

basically just mu

Question 8

butorphanol acts as a mixed agonist antagonist by

Answer 8

blocking receptors and preventing the 100% response of a full agonist

Question 9

endogenous (gut-brain) opioid peptides exist

Answer 9

yes, yes they do

Question 10

dogs tend to exihbit ___ when given analgesic agents

Answer 10

vomiting

Question 11

opioids block the release of ________… relates to the spinal cord

Answer 11

substance P

Question 12

give morphine to

Answer 12

dogs

Question 13

give butorphanol to

Answer 13

dogs, horses

Question 14

give fentanyl to

Answer 14

cats

Question 15

ventilatory depression side effect is reversed with

Answer 15

naloxone

Question 16

equine side effect

Answer 16

constipation with GI spasms (colic)

Question 17

T/F? Opioids have species dependent actions (excitability, metabolism)

Answer 17

True

Question 18

naloxine is primarily used for

Answer 18

opioid reversal

Question 19

neuroleptanalgesic preparations

Answer 19

combination of a neuroleptic (DA antagonist) with an opioid analgesic

Question 20

overall action on CNS?

Answer 20

analgesia, +/- sedation mood, respiratory depression

Question 21

overall action on GIT?

Answer 21

overall suppression (constipation, hypo-motility)