GI Drugs Flashcards
Which drugs are H2 inhibitors (H2 Antagonists)?
Ranitidine(also prokinetic), famotidine
Coating agents (area of stomach that’s damaged)
sucralfate
prokinetic agent used against ulceration
cisapride
H:K ATPase inhibitor? Give ~30min before feeding
omeprazole, pantropazole, lansoprazole
Can lead to ulcers?
NSAIDS
5 Ways we can prevent gastric ulceration?
- Antacids
- Block Acid secretion by parietal cell (H2 inhib, PPI)
- Mucosal coating agents
- PGE1 analogs (act as antacids)
- Prokinetics
Induction of vomiting
dopamine agonist, adernergic agonist, irritants
apomorphine
dopamine agonist, induces vomiting
xylazine
adrenergic agonist, induces vomiting
H2O2
irritant, induces vomiting
dexmedetomidine
adrenergic agonist induces vomitting
difference between how the dopamine and adrenergic agonists induce vomiting?
D2 ag acts on chemo-receptor trigger zone and a2 ag acts on the vomiting center
Inducing vomiting in a dog v. cat?
Apomorphine in Dogs, Xylazine in cats
Anti-emetics
M1 inhibitors H1 inhibitors antimuscarinics adrenergic antagonists neurokinin antagonists irritants (ginger) dopamine antagonists serotonin antagonists
M1 inhibitors
useful for motion sickness, not as common as H1 inhibitors
H1 inhibitors (regarding vomiting)
useful for motion sickness
Diphenhydramine, promethazine
antimuscarinics
Paralyze the gut! Doesn’t actually fix the problem! BAD
Centrine
adrenergic antagonists
prochlorperazine, acepromazine, chlorpromazine
side effect, dec. BP
Nuerokinin antagonists
maropitant (cirenia)
irritants
ginger
dopamine antagonists
metochlopramide (used to be best, but then found some brain side effects, tremors)
serotonin antagonists
ondansetron
diphenhydramine
H1 inhibitor, antiemetic
promethazine
H1 inhibitor, antiemetic
Prochlorperazine
adrenergic antagonist, antiemetic
acepromazine
adrenergic antagonist, antiemetic
maropitant
NK1 antagonist, antiemetic
metochlopramide
dopamine antagonist, antiemetic
5HT3 ant/ 5HT4 ag, prokinetic
ondansetron
serotonin antagonist, anti-emetic
centrine
antimuscarinic, anti-emetic
Prokinetics
- mixed 5HT3 antagonists/ 5HT4(serotonin) agonist
- 5HT4 agonist
- muscarinic agonists (bethanocol)
- Motilin agonist (erythromycin)
- Anticholinesterases (Ranitidine)
- Epidural analgesia (Lidocaine)
- Somatostatin Analog (octreotide)
- ginger