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Pharmacology > Anti-Histamines & Autocoid-modifying agents > Flashcards

Anti-Histamines & Autocoid-modifying agents Flashcards

1
Q

Autocoid classes

A

eicosanoids(PGE2)
polypeptides (kinin, substance P)
decarboxylated AAs (histamine and serotonin)

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2
Q

histamine released by

A

mast cells, basophils, ECL cells and CNS

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3
Q

two categories of ______, 1st and 2nd generation

A

H1 antihistamines

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4
Q

first generation can

A

cross BBB

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5
Q

limited roles in asthma or anaphylaxis

A

H1 antihistamine

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6
Q

Diphenhydramine (benadryl)

A

most common H1 antihistamine, wide use in vetmed. CNS depression

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7
Q

Cyprohepatadine

A

H1 antihistamine. mostly used as appetite stimulant.

also a serotonin antagonist

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8
Q

meclizine

A

H1 antihistamine
OTC motion sickness
vestibular syndrome in cats

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9
Q

dec. serotonin leads to bad behaviors in humans

A

yup

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10
Q

serotonin found in

A

PLATELETS, GI tissues (ECL cells), CNS

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11
Q

serotonin overdose

A

neuro signs (tremors, depression, seizures coma)
GI ( vomit, diarrhea, pain)
hyperthermia, blindness

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12
Q

amphetamines

A

inhibit serotonin storage (makes vesicles release into cleft)

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13
Q

MAOIs

A

inhibit serotonin degredation

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14
Q

Selegiline

A

MAOI

tx canine cognitive dysfunction

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15
Q

clomipramine

A

Tricyclic antidepressant

only FDA approved drug for obsessive compulsive disorders in dogs

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16
Q

fluoxetine

A

SSRI

FDA approved for separation anxiety

17
Q

fluoxetine side affect

A

anorexia

18
Q

mirtazapine

A

atypical antidepressant, do lots of mechanisms

19
Q

appetite stimulant, esp in cats

A

mirtazapine

20
Q

trazodone

A

5ht4 agonist,SSRI, anxiolytic
tx hospitalized-related anxiety,
VERY CARDIOVASCULARLY FRIENDLY

21
Q

cisapride

A

5-HT4 agonist

prokinetic - tx GI stasis

22
Q

ondansetron

A

serotonic receptor agonist, antiemetic, controversal in cats, well tolerated in dogs

Pharmacology (20 decks)

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