Anti-Histamines & Autocoid-modifying agents

Question 1

Autocoid classes

Answer 1

eicosanoids(PGE2)
polypeptides (kinin, substance P)
decarboxylated AAs (histamine and serotonin)

Question 2

histamine released by

Answer 2

mast cells, basophils, ECL cells and CNS

Question 3

two categories of ______, 1st and 2nd generation

Answer 3

H1 antihistamines

Question 4

first generation can

Answer 4

cross BBB

Question 5

limited roles in asthma or anaphylaxis

Answer 5

H1 antihistamine

Question 6

Diphenhydramine (benadryl)

Answer 6

most common H1 antihistamine, wide use in vetmed. CNS depression

Question 7

Cyprohepatadine

Answer 7

H1 antihistamine. mostly used as appetite stimulant.

also a serotonin antagonist

Question 8

meclizine

Answer 8

H1 antihistamine
OTC motion sickness
vestibular syndrome in cats

Question 9

dec. serotonin leads to bad behaviors in humans

Answer 9

yup

Question 10

serotonin found in

Answer 10

PLATELETS, GI tissues (ECL cells), CNS

Question 11

serotonin overdose

Answer 11

neuro signs (tremors, depression, seizures coma)
GI ( vomit, diarrhea, pain)
hyperthermia, blindness

Question 12

amphetamines

Answer 12

inhibit serotonin storage (makes vesicles release into cleft)

Question 13

MAOIs

Answer 13

inhibit serotonin degredation

Question 14

Selegiline

Answer 14

MAOI

tx canine cognitive dysfunction

Question 15

clomipramine

Answer 15

Tricyclic antidepressant

only FDA approved drug for obsessive compulsive disorders in dogs

Question 16

fluoxetine

Answer 16

SSRI

FDA approved for separation anxiety

Question 17

fluoxetine side affect

Answer 17

anorexia

Question 18

mirtazapine

Answer 18

atypical antidepressant, do lots of mechanisms

Question 19

appetite stimulant, esp in cats

Answer 19

mirtazapine

Question 20

trazodone

Answer 20

5ht4 agonist,SSRI, anxiolytic
tx hospitalized-related anxiety,
VERY CARDIOVASCULARLY FRIENDLY

Question 21

cisapride

Answer 21

5-HT4 agonist

prokinetic - tx GI stasis

Question 22

ondansetron

Answer 22

serotonic receptor agonist, antiemetic, controversal in cats, well tolerated in dogs