Diuretics

Question 1

used in

Answer 1

animals retaining water in various organs

Question 2

Does interference with Na+ absorption at one site interfere with other renal functions linked to it and lead to inc. Na+ absorption at other sites?

Answer 2

yes

Question 3

all diuretics, except spironolactone, act from the _________ side of the tubular cellular membrane

Answer 3

luminal!

Question 4

freely filtered at glomerulus, not metabolized, hyperosmolality creates a water shift, impairs passive water reabsorption

Answer 4

osmotic diuretics

Question 5

most common osmotic diuretic

Answer 5

mannitol

Question 6

cases of cerebral edema and inc. intracranial Pressure (ICP) should use _____, clinical effect seen in minutes (animal becomes more responsive)

Answer 6

mannitol

Question 7

contraindicated in cases of CHF

Answer 7

mannitol

Question 8

loop diuretics

Answer 8

inhibit symporter(Na, K, Cl) on luminal side, -> decrease absorption of Ca2+ Mg2+ also

Question 9

Go to drug for management of Heart failure

Answer 9

loop diuretics (furosemide)

Question 10

strongest diuretic

Answer 10

loop diuretic

Question 11

Most commonly used loop diuretic?

Answer 11

furosemide (lasix)

Question 12

effective at low glomerular filtration rates, quick, animal will pee after 20 minutes

Answer 12

furosemide

Question 13

2 main vet med diuretics

Answer 13

mannitol and furosemide

Question 14

thiazide diuretics

Answer 14

distal convoluted tubule, only 20% effective

Question 15

thiazide diuretics used often when loop diuretics have caused

Answer 15

proliferation of cells downstream (in DCT)

Question 16

increase reabsorption of Ca, helps with animals forming Ca stones

Answer 16

thiazade diuretics (hydrochlorothiazide)

Question 17

Which drug is a thiazide diuretic?

Answer 17

hydrochlorothiazide

Question 18

only mild diuretic affect, helps with hyperaldosteronemia

Answer 18

aldosterone antagonist

Question 19

which drug is aldosterone antagonist?

Answer 19

spironolactone

Question 20

diminishes the degree of K+ loss

Answer 20

spirolactone

Question 21

Carbonic anhydrase inhibitors

Answer 21

prevents formation of bicarb from h20 and C02 (pH regulation)
mild diuretic

Question 22

decrease secretion of H+ into urine, -> acidotic animal

Answer 22

CA inhibitors

Question 23

which drug is a carbonic anhydrase inhibitor

Answer 23

acetazolamide