Opioid Analgesics and Antagonists

Question 1

Opioids with the shortest and longest half-life?

Answer 1

Remifentanil: 3-4 mins
Buprenorphine: 4-8 hours

Question 2

Opioid receptor responsible for slowed gastrointestinal transit

Answer 2

Kappa

Question 3

Oral bioavailability of morphine

Answer 3

25%

Question 4

Most potent opioid

Answer 4

Ohmefentanyl

Question 5

Opioid currently being investigated as a novel treatment for leukemia

Answer 5

Methadone

Question 6

What is the mechanism of action of dextromethorphan?

Answer 6

Depresses sensitivity of cough receptors, depressing the medullary cough center through sigma receptor stimulation

Question 7

Weak opioid agonists withdrawn from the market due to fatal cardiotoxicity

Answer 7

Propoxyphene

Question 8

Antidote for opioid overdose

Answer 8

Naloxone

Question 9

Most common side effect of tramadol

Answer 9

Dizziness

Question 10

Triad of opioid overdose

Answer 10

Pupillary constriction
Comatose state
Respiratory depression

Question 11

Where does morphine exert is hemodynamic effects?

Answer 11

Pulmonary circulation

Question 12

Opioid analgesic indicated for biliary and renal spasmodic pain

Answer 12

Meperidine

Question 13

Partial opioid agonist that causes hearing loss and hypogonadism

Answer 13

Hydrocodone

Question 14

This weak opioid agonist was withdrawn from the market due to its fatal cardiotoxicity

Answer 14

Propoxyphene

Question 15

This opioid antagonist is given orally for chronic treatment of alcohol dependence

Answer 15

Naltrexone