Antidepressants

Question 1

ECG abnormalities in tricyclic antidepressant overdose (3)

Answer 1

Abnormal QRS complex morphology
Prolonged QRS duration
Abnormal size and ratio of R and S waves in aVR

Question 2

First line agent for major depressive disorder

Answer 2

Fluoxetine

Question 3

SNRI known for its hepatotoxicity

Answer 3

Duloxetine

Question 4

A patient with major depressive disorder eats wine and cheese at a party. He then develops hypertensive crisis. What antidepressant is he most likely taking?

Answer 4

Phenelzine

Question 5

First-line treatment for neuroleptic malignant syndrome

Answer 5

Diphenhydramine

Question 6

Administration of this agent reverses cardiotoxicity in overdosage of tricyclic antidepressants

Answer 6

Bicarbonate

Question 7

Two patients were given different antidepressants. On follow up, the first patient presented with erectile dysfunction whereas the second patient presented with priapism. What are the drugs that caused these side effects?

Answer 7

Erectile dysfunction: Selective serotonin reuptake inhibitors, e.g. Fluoxetine
Priapism: Quetiapine, Trazodone

Question 8

Among selective serotonin norepinephrine reuptake inhibitors, this side effect is unique to duloxetine.

Answer 8

Hepatotoxicity

Question 9

Among heterocyclic antidepressants, these drugs cause changes in weight. (1 for weight loss and 1 for weight gain)

Answer 9

Weight loss: Bupoprion

Weight gain: Mirtazapine

Question 10

Serotonin blocker used in serotonin syndrome

Answer 10

Cyproheptadine

Question 11

Fluvoxamine is indicated for?

Answer 11

Obsessive-compulsive disorder