Drugs used in Coagulation Disorders

Question 1

Local autacoid factors released by traumatized tissues and platelets

Answer 1

Thromboxane A2

Endothelin

Question 2

What disease is caused by a defect in glycoprotein 1b in the platelet surface

Answer 2

Bernard-Soulier disease

Question 3

Enumerate the three pro-aggregant substances released during the formation of the primary hemostatic plug

Answer 3

Adenosine diphosphate
Serotonin
Thromboxane A2

Question 4

What are the toxic and lethal doses of acetylsalicylic acid, respectively?

Answer 4

150 mg/kg, 500 mg/kg

Question 5

What is the triad of aspirin toxicity?

Answer 5

Samter triad: Asthma, Aspirin sensitivity, Nasal polyps

Question 6

Acid-base disorder common in adults and children in aspirin intoxication

Answer 6

High anion gap metabolic acidosis

Question 7

Among the three ADP inhibitors, where are gastrointestinal and hematologic abnormalities more common?

Answer 7

Ticlodipine

Question 8

PDE inhibitor that is contraindicated in heart failure

Answer 8

Cilostazol

Question 9

Heparin activates which enzyme?

Answer 9

Antithrombin III

Question 10

aPTT target in heparin therapy

Answer 10

1.5-2.5x of control

Question 11

Antidote for heparin

Answer 11

Protamine sulfate

Question 12

Main disadvantage of using direct thrombin inhibitors

Answer 12

No reversal agents

Question 13

Enzyme inhibited by dicumarol

Answer 13

Same with warfarin: vitamin K epoxide reductase

Question 14

Antidote for alteplase

Answer 14

Aminocaproic acid

Question 15

Clotting factors deficient in hemophilia A and B?

Answer 15

A: Factor VIII
B: Factor IX

Question 16

Form of vitamin K in green leafy vegetables

Answer 16

Phytonadione (vitamin K1)

Question 17

Desmopressin is a vasopressin V2 receptor agonist which increases factor VII activity in patients with (2) ?

Answer 17

Hemophilia A

Von Willebrand disease