Drugs used in Parkinsonism

Question 1

Hypertensive crisis is a side effect of levodopa-carbidopa when given with

Answer 1

Monoamine oxidase inhibitors

Question 2

Dopamine agonist that causes erythromelalgia and pulmonary fibrosis

Answer 2

Bromocriptine

Question 3

Dopamine agonist that causes compulsive gambling, hypersexuality, overeating, and uncontrollable tendency to fall asleep

Answer 3

Pramipexole

Question 4

Apomorphine is an opioid used as an antiparkinsonism drug. It is a partial agonist of D3 receptors but is an antagonist of what receptors?

Answer 4

5-HT and alpha receptors

Question 5

To prevent nausea in using apomorphine, patients are premedicated with …?

Answer 5

Trimethobenzamide

Question 6

A fatal reaction characterized by agitation, delirium, and death, occurs when meperidine is administered in combination with what antiparkinsonism drug?

Answer 6

Selegiline

Question 7

A patient being treated for Parkinson’s disease complains of orange discoloration of his urine. This is most likely caused by what drug?

Answer 7

COMT inhibitors: Entecapone, tolcapone

Question 8

Antiviral drug with dopaminergic activity that can be used to treat Parkinson’s disease?

Answer 8

Amantadine

Question 9

What antiparkinsonism drug is contraindicated in patients with peptic ulcer disease?

Answer 9

Pramipexole

Question 10

This drug improves tremor and rigidity in Parkinson’s disease but exacerbates tardive dyskinesias that result from prolonged use of antipsychotic drugs.

Answer 10

Benztropine