Antipsychotic Agents and Lithium

Question 1

Psychosis is caused by a relative excess of dopamine in what tracts of the brain (3)?

Answer 1

Mesocortical-mesolimbic
Nigrostriatal
Tuberoinfundibular

Question 2

Drug class that has an effect on negative symptoms of psychosis

Answer 2

Atypical antipsychotics

Question 3

Chlorpromazine and thioridazone deposit in what parts of the eye?

Answer 3

Chlorpormazine: Cornea and lens
Thioridazone: Retina

Question 4

Only antipsychotic known to reduce the risk of suicide

Answer 4

Clozapine

Question 5

Only antipsychotic approved for schizophrenia in the youth

Answer 5

Risperidone

Question 6

Five feature of neuroleptic malignant syndrome

Answer 6

Fever
Encephalopathy
Vitals unstable
Elevated CPK
Rigidity

Question 7

Teratogenic effect of lithium

Answer 7

Ebstein’s anomaly

Question 8

Only antipsychotic known to cause fatal overdose due to its strong autonomic effects

Answer 8

Thioridazine

Question 9

What is the least sedating drug among the typical antipsychotics? This drug also has the weakest autonomic effect.

Answer 9

Haloperidol

Question 10

This atypical antipsychotic can cause agranulocytosis.

Answer 10

Clozapine

Question 11

This atypical antipsychotic can cause priapism.

Answer 11

Quetiapine

Question 12

Among the atypical antipsychotics, this drug causes marked hyperprolactinemia.

Answer 12

Risperidone

Question 13

This antipsychotic is also indicated for intractable hiccups

Answer 13

Risperidone

Question 14

This dihydroindolone increases mortality in elderly patients with dementia-related psychosis. What is its effect on the ECG?

Answer 14

Ziprasidone: QT prolongation, Torsades de pointes

Question 15

This is the least sedating atypical antipsychotic.

Answer 15

Aripiprazole

Question 16

Lithium is contraindicated in patients with?

Answer 16

Sick sinus syndrome

Question 17

Threshold for toxicity of lithium

Answer 17

2 mEq/L