Antiseizure Drugs

Question 1

Antiseizure medication that is a CYP450 inhibitor

Answer 1

Valproic acid

Question 2

Acute intermittent porphyria is a side effect of which antiseizure drug class?

Answer 2

Barbiturates

Question 3

Teratogenic effect of valproic acid

Answer 3

Neural tube defects

Question 4

Drug of choice for absence seizures

Answer 4

Ethosuximide

Question 5

Most serious side effect of lamotrigine

Answer 5

Stevens-Johnson syndrome

Question 6

Levetiracetam selectively binds this synaptic vesicular protein

Answer 6

SV2A

Question 7

Drug of choice for trigeminal neuralgia

Answer 7

Carbamazepine

Question 8

Mechanism of action of hydantoin

Answer 8

Blocks voltage-gated Na+ channels

Question 9

4 features of fetal hydantoin syndrome

Answer 9

Upturned nose
Mild midfacial hypoplasia
Long upper lip with thin vermillion border
Lower distal digital hypoplasia

Question 10

What is the effect of carbamazepine, oxcarbazepine, and eslicarbazepine on glutamate?

Answer 10

Decrease glutamate release

Question 11

Baribiturates and benzodiazepines both exert their anticonvulsant effects by binding to GABA A receptors. Differentiate their effects on the chloride channel.

Answer 11

Barbiturates: Increase duration of Cl- channel opening
Benzodiazepines: Increase frequency of Cl- channel opening

Question 12

Cyclic ureides decrease Ca2+ conductance in what type of calcium channels in the brain?

Answer 12

T-type

Question 13

Preferred anticonvulsant drug in children and pregnant women

Answer 13

Phenobarbital

Question 14

Monosaccharide derivative that exerts its antiseizure effect with the most number of mechanisms of action

Answer 14

Topiramate