Histamine, Serotonin, and Ergot Alkaloids

Question 1

This is measured in the urine to detect excess histamine production

Answer 1

Imidazole acetic acid

Question 2

G protein utilized by H1 receptors

Answer 2

Gq

Question 3

Histamine receptors that primarily use Gs protein

Answer 3

H3, H4

Question 4

Antihistamine used as an adjunct in Parkinson’s disease

Answer 4

Diphenhydramine

Question 5

H1 receptor antagonist used as an anti-emetic

Answer 5

Promethazine

Question 6

Interaction between this drug class with azoles/erythromycin or terfenadine/astemizole can produce fatal arrhythmias

Answer 6

Second generation H1 receptor antagonists

Question 7

H2 receptor antagonist that has antiandrogenic effects

Answer 7

Cimetidine

Question 8

Cimetidine’s effect of CYP450

Answer 8

CYP450 inhibitor

Question 9

Excess production of this hormone can be detected by measuring 5-HIAA in the urine

Answer 9

Serotonin

Question 10

5-HT3 receptors are found mainly in this region of the CNS

Answer 10

Area postrema

Question 11

Drug of choice for acute migraine

Answer 11

Sumatriptan

Question 12

Mechanism of action of sumatriptan

Answer 12

5-HT 1D receptor agonist

Question 13

5-HT3 receptor antagonist used in irritable bowel disease

Answer 13

Alosetron

Question 14

Side effect of dolasetron in the ECG

Answer 14

QRS and QT prolongation

Question 15

The only known CNS selective ergot alkaloid

Answer 15

Lysergic acid diethylamide (LSD)

Question 16

Aside from migraine, ergonovines are used in:

Answer 16

Postpartum bleeding

Question 17

5-HT2 receptor antagonist (vasoselective) that can cause retroperitoneal fibrosis

Answer 17

Methysergide