NSAIDs, Acetaminophen, DMARDs, and Drugs used in Gout

Question 1

Long term use of this NSAID is associated with a decreased risk of colon cancer

Answer 1

Ibuprofen

Question 2

Due to the high risk of gastrointestinal and renal toxicity of ketorolac and dexketoprofen, its use is generally restricted within how many hours?

Answer 2

72

Question 3

Drug of choice in the medical closure of patent ductus arteriosus

Answer 3

Indomethacin

Question 4

Rofecoxib and valdecoxib are COX-2 inhibitors that are withdrawn from the market. What are their toxic side effects?

Answer 4

Myocardial infarction

Stroke

Question 5

Most common cause of acute liver failure

Answer 5

Acetaminophen

Question 6

Antidote for paracetamol toxicity

Answer 6

N-acetylcysteine

Question 7

Rescue agent in methotrexate toxicity

Answer 7

Leucovorin (folinic acid)

Question 8

DMARD implicated in reactivation of latent tuberculosis

Answer 8

Infliximab

Question 9

Azathioprine has a significant drug interaction with allopurinol. Concurrent administration reduces xanthine oxide catabolism, increasing 6-thioguanine nucleotides, eventually leading to …?

Answer 9

Bone marrow suppression

Question 10

MESNA is a rescue agent for which DMARD?

Answer 10

Cyclophosphamide

Question 11

DMARD that causes reversible infertility in men

Answer 11

Sulfasalazine

Question 12

NSAIDs contraindicated in gout

Answer 12

Aspirin, Tolmetin

Question 13

DMARD known to cause hemorrhagic cystitis

Answer 13

Cyclophosphamide