oncology

Question 1

what is tumour lysis syndrome?

Answer 1

destruction of the tumour cells and subsequent release of the cancer cell particles around the body leading to AKI and electrolyte abnormality

Question 2

what cancers are most likely to cause tumour lysis sydrome?

Answer 2

lymphomas and germ cell tumours

Question 3

what is the prophylaxis for tumour lysis syndrome?

Answer 3

hydration prior to chemo plus allopurinol

Question 4

what are the common cancers causing superior vena cava compression?

Answer 4

• small cell lung cancer

- lymphoma

Question 5

what is the presentation of superior vena cava compression?

Answer 5

• redness and swelling of face

- cyanosis, coma

Question 6

what is the gold standard investigation of superior vena cava compression?

Answer 6

CT chest

Question 7

what is the management of of superior vena cava compression?

Answer 7

dexamethasone ASAP + stent/radiotherapy

Question 8

what are the most common causes of neutropenic sepsis?

Answer 8

pseudomonas and fungal infections

Question 9

what is the management of neutropenic sepsis?

Answer 9

Tazosin (piperacillin/tazobactam) + gentamicin (if NEWS 7+)