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NAPLEX 21 > ONC DRUGS > Flashcards

ONC DRUGS Flashcards

1
Q

Brand: Cytoxan

A

generic: cyclophosphamide

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2
Q

Brand: Ifex

A

generic: ifosfamide

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3
Q

Brand: BiCNU

A

generic: carmustine

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4
Q

Brand: Myleran

A

generic: Busulfan

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5
Q

Brand: Adriamycin

A

generic: doxorubicin

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6
Q

Brand: Camptosar

A

generic: irinotecan

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7
Q

Brand: Navelbine

A

generic: vinblastine

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8
Q

Brand: Taxol

A

generic: paclitaxel

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9
Q

Brand: Taxotere

A

generic: docetaxel

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10
Q

Brand: Abraxane

A

generic: paclitaxel albumin bound

* no need to premedicate

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11
Q

Brand: Adrucil

A

generic: 5FU (fluorucail)

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12
Q

Brand: Xeloda

A

generic: capecitabine

PO prodrug of 5FU

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13
Q

Brand: Trexall

A

generic: methotrexate

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14
Q

Brand: Afinitor

mTOR inhibitor

A

generic: everolimus

* mouth ulcers, stomatitis, rash, peripheral edema ,inc BP

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15
Q

Bevacizumab
Ramucirumab

targets?

A

VEGF

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16
Q

Cetuximab
Panitumab

targets?

A

EGFR

17
Q

Trastuzumab

Pertuzumab

A

HER2

18
Q

Rituximab
Brentuximab
Daratumumab
Inotuzumab

A

CD20, 22, 30, 38

19
Q

Ipilimumab
Atezolizumab
Nivolumab
Pembrolizumab

A

PD1
PDL1
CTLA4

20
Q

Which drugs are correlated with a good response by showing a rash

A

cetuximab

panitumumab (EGFR)

21
Q

Hemorrhage or thrombosis may occur with these drugs

A

Bevacizumab
Ramucirumab

*impaired wound healing

22
Q

Brand: Avastin

A

generic: bevacizumab

* impaired wound healing

23
Q

Brand: Herceptin

A

generic: trastuzumab

* LVEF monitor

24
Q

Brand: Erbitux

A

generic: cetuximab

* KRAS wild type

25
Q

Brand: Rituxan

A

generic: rituximab

* premedicate with Benadryl, APAP, steroid

26
Q

Which onc drug needs to be KRAS wild type in order to use

A

cetuximab (Erbitux)

27
Q

CTLA4 inhibitor

A

ipilimumab (Yervoy)

28
Q

PD1 inhibitors

A

Pembro (Keytruda)

Nivolumab

29
Q

Gleevec

A

imatinib

30
Q

Must be Philadelphia chromosome BCR-ABL positive to use this drug class

A 
imatinib (Gleevec)
bosutinib
dasatinib
nilotinib
ponatinib

*fluid retention

31
Q

Must be BRAF V600E or V600K mutation positive

A

BRAF inhibitors:
vemurafenib
Dabrafenib

32
Q

EGFR mutation positive

A

Afatinib
Erlotinib
Getifitinib
*acneform rash = good response

33
Q

ALK positive mutation

A 
ALK inhibitors
alectinib
brigatinib
certinib
crizotinib
34
Q

Common toxicities of TKI

A 
hypothyroidism
hepatic toxicity
diarrhea
QT 
rash (good)
hand-foot syndrome
35
Q

Which oral agents do you take with food?

A

CITE

capecitabine (Xeloda)
Imatinib (Gleevec)
Thalidomide
Exemestane

36
Q

Take without regard to food

A

Tamoxifen

Anastrazole

37
Q

Thalidomide
pomalidomide
lenalidomine
are?

A

teratogenic

NAPLEX 21 (60 decks)

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