ID I: MACROLIDES Flashcards
MOA: macrolides bind to the ______ ribosomal subunitt, resulting in inhibition of RNA-dependent protein synthesis
50S
What are macrolides coverage?
atypicals (legionella, chlamydia, mycoplasma, mycobacterium avium complex)
Haemophilus
Macrolides are treatment options for:
community acquired: upper & lower respiratory tract infections
Chlamydia and gonorrhea
Brand: Zithromax, Z-pak
generic: azithromycin
Your patient is on Z-Pak, how should he take it?
500mg on day 1, then 250mg on days 2-5
You patient is on Tri-Pak, how should she take it?
500mg daily for 3 days
Brand: Biaxin
generic: Clarithromycin
Brand: EES, Ery-tab, Erythrocin
generic: erythromycin
What are contraindications with clarithromycin and erythromycin?
LOVA & SIMVA
increased risk for muscle toxicity
What are warnings for macrolides?
QT PROLONGATION (erythromycin»»)
Hepatotoxicity
Which macrolide has a caution in patients with CAD due to increased mortality even up to 1 year after the end of a TWO week course?
clarithromycin
Common Side effect of macrolides?
GI upset
Which macrolides are major substrates of 3A4?
Erythromycin and Clarithromycin
Which macrolide has fewer clinically sigificant drug interactions?
azithromycin
What are common uses for all macrolides?
CAP
an alternative to beta lactam for strep throat
