Compounding III

Question 1

Where do you review each bulk ingredient’s safety procedures for the staff

Answer 1

SDS

safety data sheets

Question 2

What is on the master formula?

Answer 2

everything that you SHOULD do

compounds official or assigned name
strength, dosage form
calculations
ingredients with quantities
stability and compatibility data with references
equipment
prep/mixng isntructions
labeling information
packaging/storage requirements
QC procedures with expected results
BUD
description of final product

Question 3

What is on the compounding record?

Answer 3

what you DID
specific to the preparation
staff involved

Question 4

BUDs for repackaged drugs should be the manufacturer’s expiration date from the

Answer 4

original container or one year from the repackaging date, whichever is earlier

Question 5

_______ means to reduce particle size by grinding, crushing, milling, vibrating or other processes

Answer 5

comminution

Question 6

Once powder has been ground, its placed in a

Answer 6

sieve (ensures uniform)

Question 7

what is the sieve number based on?

Answer 7

the number of holes per inch (#100 sieve has 100 openings/inch)

Question 8

What are the two types of comminution?

Answer 8

trituration and levigation

Question 9

a general term used to mean mix thoroughly (homogenous)

Answer 9

trituration

Question 10

Just like trituration but with a levigating agent

Answer 10

levigation

Question 11

_________ involves triturating the powder with a mortar and pestle by incorporating a small amount of liquid to help with the grinding process

Answer 11

levigation

turns a solid into a uniform paste

Question 12

_________ is similar to levigation but performed on an ointment slab with a spatula (instead of a mortar and pestle)

Answer 12

spatulation

Question 13

the method of mixing ingredients to ensure that the ingredients are evenly distributed in a diluent or delivery vehicle

Answer 13

geometric dilution

Question 14

syrups
elixirs
tinctures
spirits

Answer 14

type of solution

Question 15

a ______ is a solute disolved in a solvent (salt in water)

Answer 15

solution

*homogenous

Question 16

What will increase the dissolution rate?

Answer 16

stirring and heat

Question 17

an oral solution prepared with water as a solvent can receive a maximum BUD of _______ and should be refrigerated

Answer 17

14 days

Question 18

Emulsions can be prepared with either

Answer 18

continental gum or the English gum method

Question 19

this emulsion prep method uses oil, water and an emulsifier in a 4:2:1 mixture in the order OWE

Answer 19

congenital /dry gum

acacia, gum is levigated with oil, water is added all at once

Question 20

this emulsion prep method uses 4:2:1, oil water and emulsifier- trituration of the gum (emulsifier) and water to form a mucilage, then add oil slowly while triturating

Answer 20

English gum

it rains a lot in England (wet) and the oil is added slowly because you cannot drive too fast in the rain

the continent is dry and you can add the water quickly

Question 21

what is a. glidant/lubricant example to improve the flowability of a powder

Answer 21

mg stearate

Question 22

what is a surfactant to neutralize the static charge and keep the powder from floating away

Answer 22

sodium laurel sulfate

Question 23

examples of adsorbent powder

Answer 23

mg oxide
mg carbonate
kaolin

Question 24

a common diluent

Answer 24

lactose

Question 25

plasticers

Answer 25

glycerol

sorbitol

Question 26

lotions and ointments, which provides the most water

Answer 26

lotions = more water
ointments = least water

Question 27

BUD for a nonawueous formulation (is petroleum)

Answer 27

no later than 6 months (180 days) store at room temp

Question 28

water containing oral formulations (oral suspension)

Answer 28

no later than 14 days, fridge

Question 29

water containing topical/dermal and mucosal liquid (cream or lotion)

Answer 29

no later than 30 days - room temp