ID I: TETRACYCLINES

Question 1

MOA: tetracyclines inhibit bacterial protein synthesis by reversibly binding to the ____ ribosomal subunit

Answer 1

30S

Question 2

Tetracyclines coverage

Answer 2

gram-positive (staphylococci, streptococci, enterococci, Nocardia, Bacillus, propionibacterium)

gram-negative (Haemophilus, Moraxella, ATYPICALS)

unique…

Question 3

What unique coverage do tetracyclines have?

Answer 3

spirochetes

rickettsiae

bacillus anthraces

treponema pallidum

Question 4

Which tetracycline has broader indications?

• respiratory tract infections (CAP)
• tick-borne/rickettsial diseases
• chlamydia and gonorrhea
• CA-MRSA
• VRE UTI
• mild skin infections

Answer 4

DOXY!!!

Question 5

List the tetracyclines

Answer 5

doxycycline

minocycline

Question 6

Brand: vibramcyin

Answer 6

generic: doxycycline

Question 7

Brand: Minocin, Solodyn

Answer 7

generic: minocycline

Question 8

Which drug does NOT need renal adjustment?

Answer 8

doxycycline

Question 9

Your patient is receiving a tetracycline, what are the warnings?

Answer 9

children <8y, pregnancy and breastfeeding – discolors teeth and suppresses bone growth: DO NOT USE

Photosensitivity

Question 10

which tetracycline has a warning for DILE

Answer 10

minocycline!!

Question 11

Which tetracyclines are IV:PO 1:1

Answer 11

doxy and mino

Question 12

Tablets and capsules should be taken with 8oz of water, what extra thing do you have to do when taking doxycycline?

Answer 12

sit upright for ~30 minutes to avoid esophageal irritation

Question 13

Common uses for doxy and mino

Answer 13

CA-MRSA skin infections, acne

Question 14

Doxy is first line for…

Answer 14

• respiratory tract infections (CAP)
• COPD exacerbations
• tick-borne/rickettsial diseases/Rocky Mountain
• chlamydia and gonorrhea
• VRE UTI