ID I: MISC ABX

Question 1

Which antibiotic is a lincosamide which reversibly binds to the 50S subunit of the bacterial ribosome inhibiting protein synthesis

Answer 1

clindamycin

Question 2

Clindamycin coverage

Answer 2

anaerobes**

gram positive (CA-MRSA)

NO enterococcus or gram negatives!!!!

Question 3

What is the infamous boxed warning for clindamycin?

Answer 3

C diff

Question 4

Brand: Cleocin

Answer 4

generic: clindamycin

Question 5

A patient is receiving clindamycin for S. aureus, what should be done beforehand?

Answer 5

an induction test (D-test) should be performed to make she the S. aureus is susceptible to clindamycin by resistant to erythromycin

a flattened zone between the disks indicates inducible clindamycin resistance = don’t use

Question 6

renal adjustments in clindamycin

Answer 6

trick question, there is non

Question 7

these antibiotics cause a loss of helical dNA structure and strand breakage resulting in inhibition of protein synthesis

Answer 7

metronidazole, tinidazole, secnidazole

Question 8

Metronidazole coverage

Answer 8

anaerobes

protozoal infections

Question 9

What is metronidazole effective for?

Answer 9

bacterial vaginosis*

trichomoniasis*

giardiasis

amebiasis

c diff

combo for intra-abdominal infections*

Question 10

Brand: flagyl

Answer 10

generic: metronidazole

Question 11

IV:PO metronidazole

Answer 11

1:1

Question 12

Contraindication for metronidazole

Answer 12

pregnancy (first trimester)

alcohol or PEG products during treatment or within 3 days of D/C

Question 13

Side effects of metronidazole

Answer 13

metallic taste

Question 14

What is a side effect of secnidazole?

Answer 14

vulvovaginal candidiasis

Question 15

dosing for secnidazole

Answer 15

single dose

Question 16

What is fidaxomicin commonly used for?

Answer 16

c diff infections

*not effective for systemic infections

Question 17

Brand: dificid

Answer 17

generic: fidaxomixin

PO

Question 18

What does rifaximin cover?

Answer 18

E coli

• not effective for systemic infections
• off-label for C diff

Question 19

Rifaximin is commonly used for

PO!!

Answer 19

traveler’s diarrhea

to decrease recurrence of hepatic encephalopathy

IBS-D

Question 20

This drug inhibits bacterial cell wall synthesis by inavtivating the enzyme perusal transferase, which is critical in the synthesis of cell walls

Answer 20

fosfomycin

Question 21

what does fosfomycin cover?

Answer 21

e coli (+EBSL)

E. faecalis (VRE)

Question 22

A single dose of fosfomycin is used for

Answer 22

uncomplicated UTI (cystitis only)

Question 23

Brand: monurol

Answer 23

generic: fosfomycin

Question 24

This drug is a bacterial cell wall inhibitor that is used for uncomplicated UTI

Answer 24

nitrofurantoin

Question 25

what is nitrofurantoin’s coverage

Answer 25

E coli

klebsiella

enterobacter

s aureus

enterococcus (VRE)

Question 26

Brand: macrobid

Answer 26

generic: nitrofurantoin

Question 27

What is the dose of Macrobid for uncomplicated UTI

Answer 27

100mg BID x 5 days

Question 28

what are warnings for Macrobid?

Answer 28

hemolytic anemia (G6PD deficiency)

Question 29

Side effects of macrobid

Answer 29

brown urine

GI upset - food!!!

Question 30

Contraindicated when CrCl

Answer 30

60

Question 31

Macrobid is dosed ___ daily

Macrodantin is dosed ___ daily

Answer 31

2x

4x

Question 32

Mupirocin is a topical antimicrobial ointment used to eliminate ____ colonization of in each of the nares

Answer 32

staphylococcal MRSA colonization

Question 33

Brand: bactroban

Answer 33

generic: mupirocin