Allergic Rhinitis, Cough & Cold Flashcards
What is hay fever?
Allergic rhinitis, or simply “allergies”
While colds are caused by a virus, allergic rhinitis is caused by?
an allergen (pollen dust, pet dander)
Non-drug treatment for allergic rhinitis?
Avoiding exposure to known or suspected allergens
an IgE-mediated skin prick test or blood test can determine patient-specific allergens
Common allergens (4)
Pollens
Molds
Dust mites
Animal dander
What is the name of the index that rates the local air as good to hazardous?
AQI - air quality index
Nasal irrigation uses what types of saline solution?
isotonic and hypertonic (2-3.5%)
What is first line for chronic, mod-severe symptoms of allergic rhinitis?
intranasal steroids
especially effective in reducing the nasal symptoms of allergic rhinitis, congestion
What is first line for milder, intermittent symptoms?
oral antihistamines
little effect on nasal congestion
Brand: Rhinocort Allergy
Generic: budesonide
Brand: Flonase Allergy Relief, Flonase Sensimist, Children’s Flonase
Generic: fluticasone
Brand: Nasacort Allergy 24H & in children’s
Generic: triamsinolone
What is a common side effect from intranasal steroids?
epistaxis (nose bleeds)
How long can it take for nasal steroids to work?
1 week
What are the preferred nasal steroids in pregnancy?
budesonide and beclomethasone (Beconase AQ)
Antihistamines work by blocking histamine at the ___ receptor site
H1
first gen- more sedative
second gen- less
diphenhydramine
chlorpheniramine
doxylamine
clemastine
drug class?
First gen oral antihistamines
Brand: Aller-Chlor, Chlor-trimeton
Generic: Chlorpheniramine
Benadryl dose for adults
25-50mg PO Q4-6h (max 300mg/day)
Benadyl <6 y dose
do not use OTC, unless directed by PCP
Which drug class?
avoid in elderly
prostate enlargement
glaucoma
somnolence, cognitive impairment
first-get antihistamines
cetirizine
levocetrizine
fexofenadine
loratadine
drug class?
second gen antihistamines
Brand: Zyrtec
Generic: cetirizine
Brand: Xyzal Allergy
Generic: levocetirizine
Brand: Allegra Allergy
Generic: fexofenadine
*don’t take with juice
Brand: Claritin
Generic: loratadine
What second gen drugs are preferred in preg?
loratadine, cetirizine
Cetirizine and levocetirizine
more or less sedating?
MORE
less= fexofenadine, loratadine
Can intranasal antihistamines be combined with intranasal steroids?
yes
dymista, patanase
alpha-adrenergic agonists that cause vasoconstriction which decreases sinus vessel engorgement and mucosal edema
decongestants
Oral decongestants include
phenylephrine
pseudoephedrine
Which drug class?
C/IL within 14 days of MAO inhibitors
avoid in children <2 (FDA)
caution with CVD, BPH, urinary retention
inc HP, BP
Oral decongestants
oxymetazoline (afrin) is a ..
intranasal/topical decongestant
An OTC mast cell stabilizer used for treatment and prophylaxis of allergic rhinitis
Intranasal cromolyn (NasalCrom)
used regularly, not PRN to be effective; safe in kids and preg
the only leukotriene modifying agent indicated for the treatment of both allergic rhinitis and asthma
montelukast (Singulair)
FDA- BW for neuropsychiatric effects
contains 5 different grass pollen extracts
Oralair
contains Timothy grass pollen extract
Grastek
contains ragweed pollen extract
Ragwitek
Contains house dust mite allergen extract
Odactra
Natural products used for colds?
Zinc
Vitamin C
Echinacea
Airborne/Emergen-C
acts as a serotonin reuptake inhibitor, at high doses it acts as an NMDA-receptor blocker leading to euphoria and hallucinations similar to PCP
dextromethorphan
“DM”
many states ban the sale to minors
Codeine listed as a CII used for:
pain
Codeine listed as a C-V used for:
cough and cold
BW: respiratory depression and death have occurred in children who have received this drug following tonsillectomy and or adenoidectomy and have evidence of being ultra-rapid metabolizers due to a 2D6 polymorphism
Codeine
do not use in children <12
or <18 for said surgeries
The FDA recommends to avoid codeine-containing cough and cold products for patients
<18
Brand: Tessalon Perles
benzonatate
Brand: Bromfed DM
Generic: Brompheniramine/psueoephedrine/dextromethoprphan
AC means what is inside?
codeine
Brand: TussiCapsm
Generic: Chlorpheniramine/hydrocodone
C-II
Promethazine/codeine
control?
C-V
guafenensin/codeine
control?
C-V
Guafenesin/codeine/pseudoephdrine
control?
C-V
What products need to be avoided in children <2?
OTC cough and cold products
promethazine
topical menthol and camphor (Vicks)