Infectious Diseases II Flashcards
Infuse cefazolin or cefuroxime ___ min before start of surgery
60 min
If a quinolone or Vanc are used, start the infusion ___ min before start of surgery
120 min
Give additional dose/s if surgery is >__ hours, or with major blood loss
3-4h
Post-surgery, abc are not used; d/c within __ hrs
24h
This abx is preferred for most surgeries to prevent MSSA and streptococci infections; what is an alternative if a B-lactam allergy?
Cefazolin, a first generation cephalosporin; or a second-gen ceph: cefuroxime
Alt: clindamycin
In colorectal surgeries, the prophylactic regimen needs to cover skin flora + broad gram (-) and anaerobic organisms found in the gut. Recommended antibiotics:
Cefotetan, cefoxitin, ampicillin/sulbactam, ertapenem, or
metronidazole + (cefazolin or ceftriaxone)
Colorectal surgery prophylaxis, if beta-lactam allergy present
Clindamycin + (AG, quinolone, or Aztreonam) or
metronidazole + (AG or quinolone)
Cardiac or vascular surgery prophylaxis
Cefazolin or cefuroxime
BL allergy: vancomycin or clindamycin
Hip fracture of total joint replacement surgery prophylaxis
Cefazolin
BL allergy: vancomycin or clindamycin
Meningitis- this bacterium is prevalent in neonates, age >50y, and immunocompromised groups and requires additional treatment with ampicillin
Listeria monocytogenes
Common bacteria: S. pneumoniae, Neisseria meningitides, and H. influenzae
Acute bacterial meningitis tx (CA)- Antibiotic durations: - N. meningitidis: - H. influenzae: - S. Pneumoniae: - Listeria Monocytogenes:
Antibiotic durations:
- N. meningitidis: 7 days
- H. influenzae: 7 days
- S. Pneumoniae: 10-14 days
- Listeria Monocytogenes: 21 days
Acute bacterial meningitis tx (CA)-
To prevent neurological complications, _____ can be given prior to or with the first antibiotic dose
20 mins prior to dose, Dexamethasone 0.15mg/kg IV Q6H x 4 days
Treatment for acute Otitis media in children
amoxicillin 80-90mg/kg/day BID OR amox/clav. 90mg/kg/day + 6.4mg/kg/day BID.
If vomiting: ceftriaxone 50mg/kg IM or IV x 1-3days
The high amoxicillin doses are needed to cover most strains of S. pneumoniae
NOTES:
With amox/clav, the formulation with the LEAST amt of clavulanate should be used to dec the risk of diarrhea. 14:1 ratio –> amoxicillin 600mg and clavulanate 42.9mg/5mL
Acute otitis media treatment in kids: when to consider observation?
How many days? & Temp < ??
Age 6-23 months sx?
Age >2y sx?
try observation for 2-3 days if mild ear pain and temp <102.2F and:
- age 6-23 months: sx in one ear only
- age >2y: sx in one or both ears
Pharyngitis treatment
Penicilllin,
amoxicillin
or 1st/2nd gen cephalosporin (cefazolin, cefuroxime, cefotetan) x 10 days
azithromycin x 5 days
Sinusitis treatment
First line: amox/clav
Second line or failure of first: oral 2nd/3rd gen cephalosporin +clindamycin, doxycycline, or a respiratory quinolone (GML)
Influenza treatment
Oseltamivir x 5 days
Baloxavir x 1 dose
Zanamivir inhalation x 5 days
Acute bronchitis treatment
Supportive; abx are not recommended unless pneumonia is present.
The exception is Bordetella pertussis (macrolide - azithromycin, clarithromycin or Bactrim)
Acute bacterial exacerbation of chronic bronchitis can be referred to as a
COPD exacerbation
COPD exacerbation treatment
Supportive treatment (O2, short-acting bronchodilators, IV or PO steroids)
When should abx be given in a COPD exacerbation? (tx is for 5-7 days)
- All of the following: INC dyspnea, INC sputum volume, INC sputum purulence
- INC sputum purulence + 1 additional sx
- mechanically ventilated
What are the preferred antibiotics in a COPD exacerbation?
Amoxicillin/Clavulanate
Azithromycin
Doxycycline
A chest X-ray is the gold standard test for the diagnosis of _____ and will have infiltrates, opacities or consolidations
Community-acquired pneumonia
Most bacterial CAP cases are caused by
S. pneumoniae, H. influenzae, M. Pneumoniae, and possibly C. Pneumoniae
What is the duration for treatment for CAP?
5-7 days
Outpatient treatment of CAP requires an assessment of pt comorbidities and risk factors for drug-resistant pathogens. Patients with comorbidities or immunosuppression require:
broader coverage of possible drug-resistant S. pneumoniae
Step 1 of the outpatient CAP assessment
Look for comorbities (CHF, lung, liver, or renal disease, diabetes, alcoholism, cancer, or asplenia)
Step 2 of the outpatient CAP assessment
Check for MRSA or P.aerugenisoa risk factors, receipt of parenteral abx
Recommended empiric regimen for CAP if patient does not have any comorbidities
Amoxicillin high-dose (1 gram TID), or
Doxycycline, or
Macrolide (azithromycin or clarithromycin) if local pneumococcal resistance is <25%
Recommended empiric regimen for CAP if patient does have comorbidities
Beta-lactam + macrolide or doxycycline
- Amox/Clav or (cefpodoxime, cefdinir, cefuroxime) plus - macrolide or doxycycline
Respiratory quinolone mono therapy (GML)
Inpatient CAP treatment: selection of an empiric regimen is based on:
severity of illness and often includes IV abx initially
Inpatient CAP tx: non-severe/ non-ICU care
- Beta-lactam + macrolide or doxycycline
- preferred beta-lactams: ceftriaxone, cefotaxime, ceftaroline, or amp/sulbactam
- Respiratory quinolone monotherapy
Inpatient CAP tx: severe/ICU care
Beta-lactam + macrolide
Beta-lactam + respiratory quinolone (do NOT use quinolone as mono therapy)
Inpatient CAP tx: concern for MRSA.
Add coverage with:
add coverage with vancomycin or linezolid
Inpatient CAP tx: concern for pseudomonas
Add coverage with:
add coverage with pip/tazo, cefepime, merwpenam, Aztreonam, ceftazidime
Hospital-acquired pneumonia (HAP) has an onset of >___ hours after hospital admission
> 48 hours – HAP is the leading infectious cause of death in ICU patients
Ventilator-associated pneumonia (VAP) occurs > ___ hours after the start of mechanical ventilation
> 48 hours;
rate of VAP can be reduced by:
-proper handwashing
- elevating the head of the bed >30 degrees
- weaning off the ventilator ASAP
- removing NG tubes
- D/C unnecessary stress ulcer prophylaxis
Nosocomial pathogens are common in these infectious situations; the risk for MRSA and MDR gram-negative rods, including P. aeruginosa, acinetobacter spp, enterobacter spp, E.coli and Klebsiella spp is increased in selected cases
HAP & VAP
Empiric Regimen: HAP/VAP
Patient has a low risk for MRSA or MDR pathogens
Choose 1 abx:
Cefepime or
pip/tazo
Empiric Regimen: HAP/VAP
Patient has a risk for MRSA, but low risk of MDR pathogens
Choose 2 abx:
- cefepime + vancomycin
- Meropenem + linezolid
Empiric Regimen: HAP/VAP
Patient has a risk for both MRSA and MDR pathogens (IV abx within the past 90 days)
Choose 3 abx:
- pip/tazo + ciprofloxacin + vancomycin
- cefepime + gentamicin + linezolid
- Positive MRSA nasal swab
- high prevalence of resistant pathogen noted in hospital unit
- IV antibiotics use within the past 90 days
are all high risk of
MRSA or MDR pathogens
List antibiotics for pseudomonas
PSEUDOMONAS –
Pip/tazo
Cefepime, ceftazidime, or ceftolozane/tazo
Quinolones: Levofloxacin or ciprofloxacin
Carbapenems: Imipenem/cilastatin or meropenem
AG: Tobramycin, gentamicin or amikacin (not mono)
Antibiotics for MRSA
Vancomycin or linezolid
Active pulmonary TB is transmitted by
aerosolized droplets (sneezing, coughing, talking) & highly contagious
Presents with cough/hemoptysis, purulent sputum, fever, and night sweats
A false positive TB (TST) test can occur in those who have received what vaccine?
Bacille Calmette-Gurein (BCG) vaccine
Latent TB treatment: shorter regimens are preferred (3-4 months) due to higher completion rates and less risk of
hepatotoxicity
Latent TB treatment: this regimen is once weekly x 12 weeks via directly observed therapy or self-administered
INH and rifapentine once weekly x 12 weeks
Strongly recommended in adults, children >2y, and HIV patients.
NOT for pregnant women.
Latent TB treatment: This regimen is a preferred regimen in children of all ages and HIV-negative adults
Rifampin 600mg daily x 4 months
Drug interactions :(
Latent TB treatment: this regimen is daily x 3 months and can be used in adults, children of all ages, and HIV+ patients
Isoniazid + rifampin daily x 3 months