Autoimmune Conditions: SLE Flashcards
This condition affects young women, with a female:male ratio of
10:1
This disease predominantly is more common in women of what descent?
african-american and asian
What drugs can cause DILE?
Methimazole
Peropylthiourical
Methyldopa
Minocycline
Procainamide
Hydralazine/ BiDil
Anti-TNF agents
Terbinafine
Isoniazid
Quinidine
“My Pretty Malar Marketing Probably Has A Transient Important Quality”
The most common symptoms of SLE?
fatigue
depression
anorexia
weight loss
muscle pain
malar rash/butterfly
photosensitivity
joint pain/stiffness
what develops in over 50% of patients with SLE?
Lupus nephritis
What are common lab findings that can confirm diagnosis
positive ANA, anti-ssDNA, anti-dsDNA
Non-drug treatment?
rest
exercise
smoking cessation
sunscreens and sun protection
What are options for chronic therapy?
hydroxychloroquine
cyclophosphamide
azathioprine
mycophenolate mofetil
cyclosporine
In some cases, it may take up to __ months to see maximal benefit from treatment
6 months
Brand: Belysta
generic: belimumab
can have fatal infections, do not give with other DMARDs or live vaccines
an IgG1-lambda monoclonal antibody: prevents the survival of B lymphocytes by blocking the binding of soluble human B lymphocyte stimulator protein (BLyS) to receptors on B lymphocytes; this reduces the activity of B cell mediated immunity and the autoimmune response
belimumab
