Neuron And Action Potential Flashcards
What are the two parts of the Nervous system and their functions?
Central Nervous System:
- Integrates signals
- Sends signals to PNS
Peripheral Nervous system:
- Senses input
- Relays input to muscles
What are the two types of synapses in neurons?
- Electrical synapse/Gap junction
2. Chemical synapse
What is syncytium?
When an AP is elicited anywhere within a muscle mass, it generally travels in all directions in the muscle
Aka all cell act in synch
Which the cells are responsible for creating the myelin sheath?
CNS: Oligodenrocytes
PNS: Shwann cells
What are the roles of supporting cells of the CNS?
Ependymal cells: assist in producing and circulating CSF
Astrocytes: Maintain BBB
Oligodendrocytes: Increase conduction via myelin sheath
Microglia: Remveal of debris and waste via phagocytosis
Describe graded potential vs action potential.
In Graded Potential, there are a variable amounts of changes in charge; Cell body,dendrite
In action potential, Changes in charge are always identical; Axons
What is the resting potential of most neurons?
-80 to -60 mV
Differentiate Absolute Refractory period vs Relative Refractory period.
ARP: AP cannot be generated regardless of stimulus intensity. Due to closure of Na+ channel inactivation gate
RRP: Due to inactivated conformation of the voltage gated Na channels; Conductance of K+ is higher than the resting potential, so the membrane potential becomes more negative
Describe the pathology and symptoms of Multiple Sclerosis.
- Autoimmune disorder where immune cells attack myelin sheath
- Reduced conductance of neurons
- Loss of sheath leads to leakage of K+
- Partial loss of vision and problems with speech, balance,m and motor coordination
What are the types of propagation and where are they located?
Continuous -> Unmyelinated
Saltatory -> Myelinated
How are NTs transported down the axon?
In vesicles don microtubules via dynein and kinesin
What are the 3 types of ion channels on neurons?
- Stretch-gated
- Ligand gated
- Voltage gated
What determines Nt release?
- INC calcium into the presynaptic axon causes exocytosis of vesicle contents into synapse
- Concentration of Ca++ determines concentration of NT released
Describe Lambert-Eaton syndrome.
- Autoimmune
- Antibodies attack voltage-gated calcium channels on presynaptic axon terminal
- Impairs NT release
- Characterized by general muscle weakness
Describe Gillian-Barre Syndrome.
- Severe autoimmune disorder
- Immunologic destruction of Schwann cells, nerve roots, and ganglia
- Manifests as ascending weakness/paralysis
- Rapidly travels upward, and result in fatal respiratory paralysis
- prompt care to decrease inflammation can help recover normal function and demyelination of nerves